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Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds

Author

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  • Takashi Yoshimura

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho)

  • Shinobu Yasuo

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho)

  • Miwa Watanabe

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho)

  • Masayuki Iigo

    (Utsunomiya University, Mine-Machi)

  • Takashi Yamamura

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho)

  • Kanjun Hirunagi

    (The Nagoya University Museum, Furo-cho)

  • Shizufumi Ebihara

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho)

Abstract

Reproduction of many temperate zone birds is under photoperiodic control. The Japanese quail is an excellent model for studying the mechanism of photoperiodic time measurement because of its distinct and marked response to changing photoperiods. Studies on this animal have suggested that the mediobasal hypothalamus (MBH) is an important centre controlling photoperiodic time measurement1,2,3,4,5,6,7,8. Here we report that expression in the MBH of the gene encoding type 2 iodothyronine deiodinase (Dio2), which catalyses the intracellular deiodination of thyroxine (T4) prohormone to the active 3,5,3′-triiodothyronine (T3), is induced by light in Japanese quail. Intracerebroventricular administration of T3 mimics the photoperiodic response, whereas the Dio2 inhibitor iopanoic acid prevents gonadal growth. These findings demonstrate that light-induced Dio2 expression in the MBH may be involved in the photoperiodic response of gonads in Japanese quail.

Suggested Citation

  • Takashi Yoshimura & Shinobu Yasuo & Miwa Watanabe & Masayuki Iigo & Takashi Yamamura & Kanjun Hirunagi & Shizufumi Ebihara, 2003. "Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds," Nature, Nature, vol. 426(6963), pages 178-181, November.
    • Handle: RePEc:nat:nature:v:426:y:2003:i:6963:d:10.1038_nature02117
    DOI: 10.1038/nature02117
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    Cited by:

    1. Yusuke Nakane & Ai Shinomiya & Wataru Ota & Keisuke Ikegami & Tsuyoshi Shimmura & Sho-Ichi Higashi & Yasuhiro Kamei & Takashi Yoshimura, 2019. "Action spectrum for photoperiodic control of thyroid-stimulating hormone in Japanese quail (Coturnix japonica)," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-15, September.

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