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Differential regulation of EIN3 stability by glucose and ethylene signalling in plants

Author

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  • Shuichi Yanagisawa

    (Okayama University
    Harvard Medical School)

  • Sang-Dong Yoo

    (Harvard Medical School)

  • Jen Sheen

    (Harvard Medical School)

Abstract

Glucose is a global regulator of growth and metabolism that is evolutionarily conserved from unicellular microorganisms to multicellular animals and plants1. In photosynthetic plants, glucose shows hormone-like activities and modulates many essential processes, including embryogenesis, germination, seedling development, vegetative growth, reproduction and senescence2,3. Genetic and phenotypic analyses of Arabidopsis mutants with glucose-insensitive (gin) and glucose-oversensitive (glo) phenotypes have identified an unexpected antagonistic interaction between glucose and the plant stress hormone ethylene. The ethylene-insensitive etr1 and ein2 mutants have glo phenotypes, whereas the constitutive ethylene signalling mutant ctr1 is allelic to gin4 (refs 4, 5). The precise molecular mechanisms underlying the complex signalling network that governs plant growth and development in response to nutrients and plant hormones are mostly unknown. Here we show that glucose enhances the degradation of ETHYLENE-INSENSITIVE3 (EIN3), a key transcriptional regulator in ethylene signalling6,7, through the plant glucose sensor hexokinase8. Ethylene, by contrast, enhances the stability of EIN3. The ein3 mutant has a glo phenotype, and overexpression of EIN3 in transgenic Arabidopsis decreases glucose sensitivity.

Suggested Citation

  • Shuichi Yanagisawa & Sang-Dong Yoo & Jen Sheen, 2003. "Differential regulation of EIN3 stability by glucose and ethylene signalling in plants," Nature, Nature, vol. 425(6957), pages 521-525, October.
    • Handle: RePEc:nat:nature:v:425:y:2003:i:6957:d:10.1038_nature01984
    DOI: 10.1038/nature01984
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    Cited by:

    1. Cui Zhang & Yunyuan Xu & Siyi Guo & Jiaying Zhu & Qing Huan & Huanhuan Liu & Lei Wang & Guanzheng Luo & Xiujie Wang & Kang Chong, 2012. "Dynamics of Brassinosteroid Response Modulated by Negative Regulator LIC in Rice," PLOS Genetics, Public Library of Science, vol. 8(4), pages 1-14, April.

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