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Control of leaf morphogenesis by microRNAs

Author

Listed:
  • Javier F. Palatnik

    (Max Planck Institute for Developmental Biology
    The Salk Institute for Biological Studies)

  • Edwards Allen

    (Oregon State University)

  • Xuelin Wu

    (The Salk Institute for Biological Studies)

  • Carla Schommer

    (Max Planck Institute for Developmental Biology)

  • Rebecca Schwab

    (Max Planck Institute for Developmental Biology)

  • James C. Carrington

    (Oregon State University)

  • Detlef Weigel

    (Max Planck Institute for Developmental Biology
    The Salk Institute for Biological Studies)

Abstract

Plants with altered microRNA metabolism have pleiotropic developmental defects, but direct evidence for microRNAs regulating specific aspects of plant morphogenesis has been lacking. In a genetic screen, we identified the JAW locus, which produces a microRNA that can guide messenger RNA cleavage of several TCP genes controlling leaf development. MicroRNA-guided cleavage of TCP4 mRNA is necessary to prevent aberrant activity of the TCP4 gene expressed from its native promoter. In addition, overexpression of wild-type and microRNA-resistant TCP variants demonstrates that mRNA cleavage is largely sufficient to restrict TCP function to its normal domain of activity. TCP genes with microRNA target sequences are found in a wide range of species, indicating that microRNA-mediated control of leaf morphogenesis is conserved in plants with very different leaf forms.

Suggested Citation

  • Javier F. Palatnik & Edwards Allen & Xuelin Wu & Carla Schommer & Rebecca Schwab & James C. Carrington & Detlef Weigel, 2003. "Control of leaf morphogenesis by microRNAs," Nature, Nature, vol. 425(6955), pages 257-263, September.
    • Handle: RePEc:nat:nature:v:425:y:2003:i:6955:d:10.1038_nature01958
    DOI: 10.1038/nature01958
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