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Cell survival and a Gadd45-factor deficiency

Author

Listed:
  • Arshad Amanullah

    (Temple University School of Medicine
    HTB/Integrative Biology Initiative, GlaxoSmithKline)

  • Naiyer Azam

    (Temple University School of Medicine)

  • Arthur Balliet

    (Temple University School of Medicine)

  • Christine Hollander

    (Gene Response Section, Center for Cancer Research, National Cancer Institute, NIH)

  • Barbara Hoffman

    (Temple University School of Medicine)

  • Albert Fornace

    (Gene Response Section, Center for Cancer Research, National Cancer Institute, NIH)

  • Dan Liebermann

    (Temple University School of Medicine)

Abstract

Tumour-necrosis factor-α (TNF-α) is an important protein that regulates inflammation, immunity, cell survival and cell death in response to infection or chronic stress1,2,3,4,5. De Smaele et al. report that the gene encoding an inducible cellular factor, Gadd45β (for 'growth arrest and DNA damage'), is essential for promoting TNF-α-mediated cell survival6. However, we show here that neither TNF-α signalling nor cell survival is affected in mice lacking gadd45β, a fact which demonstrates that genes other than gadd45β (refs 5, 7) might regulate cell survival in response to TNF-α.

Suggested Citation

  • Arshad Amanullah & Naiyer Azam & Arthur Balliet & Christine Hollander & Barbara Hoffman & Albert Fornace & Dan Liebermann, 2003. "Cell survival and a Gadd45-factor deficiency," Nature, Nature, vol. 424(6950), pages 741-741, August.
    • Handle: RePEc:nat:nature:v:424:y:2003:i:6950:d:10.1038_424741b
    DOI: 10.1038/424741b
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