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Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates

Author

Listed:
  • Nancy J. Sullivan

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Thomas W. Geisbert

    (United States Army Medical Research Institute of Infectious Diseases)

  • Joan B. Geisbert

    (United States Army Medical Research Institute of Infectious Diseases)

  • Ling Xu

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Zhi-yong Yang

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Mario Roederer

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Richard A. Koup

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Peter B. Jahrling

    (United States Army Medical Research Institute of Infectious Diseases)

  • Gary J. Nabel

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

Abstract

Containment of highly lethal Ebola virus outbreaks poses a serious public health challenge. Although an experimental vaccine has successfully protected non-human primates against disease1, more than six months was required to complete the immunizations, making it impractical to limit an acute epidemic. Here, we report the development of accelerated vaccination against Ebola virus in non-human primates. The antibody response to immunization with an adenoviral (ADV) vector encoding the Ebola glycoprotein (GP) was induced more rapidly than with DNA priming and ADV boosting, but it was of lower magnitude. To determine whether this earlier immune response could nonetheless protect against disease, cynomolgus macaques were challenged with Ebola virus after vaccination with ADV–GP and nucleoprotein (NP) vectors. Protection was highly effective and correlated with the generation of Ebola-specific CD8+ T-cell and antibody responses. Even when animals were immunized once with ADV–GP/NP and challenged 28 days later, they remained resistant to challenge with either low or high doses of virus. This accelerated vaccine provides an intervention that may help to limit the epidemic spread of Ebola, and is applicable to other viruses.

Suggested Citation

  • Nancy J. Sullivan & Thomas W. Geisbert & Joan B. Geisbert & Ling Xu & Zhi-yong Yang & Mario Roederer & Richard A. Koup & Peter B. Jahrling & Gary J. Nabel, 2003. "Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates," Nature, Nature, vol. 424(6949), pages 681-684, August.
    • Handle: RePEc:nat:nature:v:424:y:2003:i:6949:d:10.1038_nature01876
    DOI: 10.1038/nature01876
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    Cited by:

    1. Jade Mitchell & Kara Dean & Charles Haas, 2020. "Ebola Virus Dose Response Model for Aerosolized Exposures: Insights from Primate Data," Risk Analysis, John Wiley & Sons, vol. 40(11), pages 2390-2398, November.
    2. Nicholas V. Olijnyk, 2015. "An algorithmic historiography of the Ebola research specialty: mapping the science behind Ebola," Scientometrics, Springer;Akadémiai Kiadó, vol. 105(1), pages 623-643, October.

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