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Machinery for protein sorting and assembly in the mitochondrial outer membrane

Author

Listed:
  • Nils Wiedemann

    (Universität Freiburg
    Universität Freiburg)

  • Vera Kozjak

    (Universität Freiburg
    Universität Freiburg)

  • Agnieszka Chacinska

    (Universität Freiburg)

  • Birgit Schönfisch

    (Universität Freiburg)

  • Sabine Rospert

    (Max-Planck Research Unit Enzymology of Protein Folding)

  • Michael T. Ryan

    (Universität Freiburg
    La Trobe University)

  • Nikolaus Pfanner

    (Universität Freiburg)

  • Chris Meisinger

    (Universität Freiburg)

Abstract

Mitochondria contain translocases for the transport of precursor proteins across their outer and inner membranes1,2,3,4,5. It has been assumed that the translocases also mediate the sorting of proteins to their submitochondrial destination1,2,5,6,7,8,9,10. Here we show that the mitochondrial outer membrane contains a separate sorting and assembly machinery (SAM) that operates after the translocase of the outer membrane (TOM). Mas37 forms a constituent of the SAM complex. The central role of the SAM complex in the sorting and assembly pathway of outer membrane proteins explains the various pleiotropic functions that have been ascribed to Mas37 (refs 4, 11–15). These results suggest that the TOM complex, which can transport all kinds of mitochondrial precursor proteins, is not sufficient for the correct integration of outer membrane proteins with a complicated topology, and instead transfers precursor proteins to the SAM complex.

Suggested Citation

  • Nils Wiedemann & Vera Kozjak & Agnieszka Chacinska & Birgit Schönfisch & Sabine Rospert & Michael T. Ryan & Nikolaus Pfanner & Chris Meisinger, 2003. "Machinery for protein sorting and assembly in the mitochondrial outer membrane," Nature, Nature, vol. 424(6948), pages 565-571, July.
    • Handle: RePEc:nat:nature:v:424:y:2003:i:6948:d:10.1038_nature01753
    DOI: 10.1038/nature01753
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    Cited by:

    1. Adinarayana Marada & Corvin Walter & Tamara Suhm & Sahana Shankar & Arpita Nandy & Tilman Brummer & Ines Dhaouadi & F.-Nora Vögtle & Chris Meisinger, 2024. "DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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