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WAVE2 is required for directed cell migration and cardiovascular development

Author

Listed:
  • Daisuke Yamazaki

    (University of Tokyo
    CREST, Japan Science and Technology Corporation)

  • Shiro Suetsugu

    (University of Tokyo
    CREST, Japan Science and Technology Corporation)

  • Hiroaki Miki

    (University of Tokyo
    PRESTO, Japan Science and Technology Corporation)

  • Yuki Kataoka

    (University of Tokyo)

  • Shin-Ichi Nishikawa

    (Kyoto University)

  • Takashi Fujiwara

    (Ehime University School of Medicine)

  • Nobuaki Yoshida

    (University of Tokyo)

  • Tadaomi Takenawa

    (University of Tokyo
    CREST, Japan Science and Technology Corporation)

Abstract

WAVE2, a protein related to Wiskott–Aldrich syndrome protein, is crucial for Rac-induced membrane ruffling, which is important in cell motility1,2,3,4. Cell movement is essential for morphogenesis, but it is unclear how cell movement is regulated or related to morphogenesis. Here we show the physiological functions of WAVE2 by disruption of the WAVE2 gene in mice. WAVE2 was expressed predominantly in vascular endothelial cells during embryogenesis. WAVE2-/- embryos showed haemorrhages and died at about embryonic day 10. Deficiency in WAVE2 had no significant effect on vasculogenesis, but it decreased sprouting and branching of endothelial cells from existing vessels during angiogenesis. In WAVE2-/- endothelial cells, cell polarity formed in response to vascular endothelial growth factor, but the formation of lamellipodia at leading edges and capillaries was severely impaired. These findings indicate that WAVE2-regulated actin reorganization might be required for proper cell movement and that a lack of functional WAVE2 impairs angiogenesis in vivo.

Suggested Citation

  • Daisuke Yamazaki & Shiro Suetsugu & Hiroaki Miki & Yuki Kataoka & Shin-Ichi Nishikawa & Takashi Fujiwara & Nobuaki Yoshida & Tadaomi Takenawa, 2003. "WAVE2 is required for directed cell migration and cardiovascular development," Nature, Nature, vol. 424(6947), pages 452-456, July.
    • Handle: RePEc:nat:nature:v:424:y:2003:i:6947:d:10.1038_nature01770
    DOI: 10.1038/nature01770
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    Cited by:

    1. Shinya Yuge & Koichi Nishiyama & Yuichiro Arima & Yasuyuki Hanada & Eri Oguri-Nakamura & Sanshiro Hanada & Tomohiro Ishii & Yuki Wakayama & Urara Hasegawa & Kazuya Tsujita & Ryuji Yokokawa & Takashi M, 2022. "Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins," Nature Communications, Nature, vol. 13(1), pages 1-25, December.

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