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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Author

Listed:
  • Coleen T. Murphy

    (University of California)

  • Steven A. McCarroll

    (University of California)

  • Cornelia I. Bargmann

    (University of California)

  • Andrew Fraser

    (University of Cambridge)

  • Ravi S. Kamath

    (University of Cambridge)

  • Julie Ahringer

    (University of Cambridge)

  • Hao Li

    (University of California)

  • Cynthia Kenyon

    (University of California)

Abstract

Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription factor, influences the rate of ageing of Caenorhabditis elegans in response to insulin/insulin-like growth factor 1 (IGF-I) signalling. Using DNA microarray analysis, we have found that DAF-16 affects expression of a set of genes during early adulthood, the time at which this pathway is known to control ageing. Here we find that many of these genes influence the ageing process. The insulin/IGF-I pathway functions cell non-autonomously to regulate lifespan, and our findings suggest that it signals other cells, at least in part, by feedback regulation of an insulin/IGF-I homologue. Furthermore, our findings suggest that the insulin/IGF-I pathway ultimately exerts its effect on lifespan by upregulating a wide variety of genes, including cellular stress-response, antimicrobial and metabolic genes, and by downregulating specific life-shortening genes.

Suggested Citation

  • Coleen T. Murphy & Steven A. McCarroll & Cornelia I. Bargmann & Andrew Fraser & Ravi S. Kamath & Julie Ahringer & Hao Li & Cynthia Kenyon, 2003. "Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans," Nature, Nature, vol. 424(6946), pages 277-283, July.
    • Handle: RePEc:nat:nature:v:424:y:2003:i:6946:d:10.1038_nature01789
    DOI: 10.1038/nature01789
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    Cited by:

    1. Samim Sharifi & Prerana Chaudhari & Asya Martirosyan & Alexander Otto Eberhardt & Finja Witt & André Gollowitzer & Lisa Lange & Yvonne Woitzat & Eberechukwu Maryann Okoli & Huahui Li & Norman Rahnis &, 2024. "Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Maria E. Lima & Ana C. Colpo & Willian G. Salgueiro & Guilherme E. Sardinha & Daiana S. Ávila & Vanderlei Folmer, 2014. "Ilex paraguariensis Extract Increases Lifespan and Protects Against the Toxic Effects Caused by Paraquat in Caenorhabditis elegans," IJERPH, MDPI, vol. 11(10), pages 1-14, September.
    3. Mitchell P Levesque & Teva Vernoux & Wolfgang Busch & Hongchang Cui & Jean Y Wang & Ikram Blilou & Hala Hassan & Keiji Nakajima & Noritaka Matsumoto & Jan U Lohmann & Ben Scheres & Philip N Benfey, 2006. "Whole-Genome Analysis of the SHORT-ROOT Developmental Pathway in Arabidopsis," PLOS Biology, Public Library of Science, vol. 4(5), pages 1-1, May.

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