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The DNA sequence of human chromosome 7

Author

Listed:
  • LaDeana W. Hillier

    (Genome Sequencing Center, Washington University School of Medicine)

  • Robert S. Fulton

    (Genome Sequencing Center, Washington University School of Medicine)

  • Lucinda A. Fulton

    (Genome Sequencing Center, Washington University School of Medicine)

  • Tina A. Graves

    (Genome Sequencing Center, Washington University School of Medicine)

  • Kymberlie H. Pepin

    (Genome Sequencing Center, Washington University School of Medicine)

  • Caryn Wagner-McPherson

    (Genome Sequencing Center, Washington University School of Medicine)

  • Dan Layman

    (Genome Sequencing Center, Washington University School of Medicine)

  • Jason Maas

    (Genome Sequencing Center, Washington University School of Medicine)

  • Sara Jaeger

    (Genome Sequencing Center, Washington University School of Medicine)

  • Rebecca Walker

    (Genome Sequencing Center, Washington University School of Medicine)

  • Kristine Wylie

    (Genome Sequencing Center, Washington University School of Medicine)

  • Mandeep Sekhon

    (Genome Sequencing Center, Washington University School of Medicine)

  • Michael C. Becker

    (Genome Sequencing Center, Washington University School of Medicine)

  • Michelle D. O'Laughlin

    (Genome Sequencing Center, Washington University School of Medicine)

  • Mark E. Schaller

    (Genome Sequencing Center, Washington University School of Medicine)

  • Ginger A. Fewell

    (Genome Sequencing Center, Washington University School of Medicine)

  • Kimberly D. Delehaunty

    (Genome Sequencing Center, Washington University School of Medicine)

  • Tracie L. Miner

    (Genome Sequencing Center, Washington University School of Medicine)

  • William E. Nash

    (Genome Sequencing Center, Washington University School of Medicine)

  • Matt Cordes

    (Genome Sequencing Center, Washington University School of Medicine)

  • Hui Du

    (Genome Sequencing Center, Washington University School of Medicine)

  • Hui Sun

    (Genome Sequencing Center, Washington University School of Medicine)

  • Jennifer Edwards

    (Genome Sequencing Center, Washington University School of Medicine)

  • Holland Bradshaw-Cordum

    (Genome Sequencing Center, Washington University School of Medicine)

  • Johar Ali

    (Genome Sequencing Center, Washington University School of Medicine)

  • Stephanie Andrews

    (Genome Sequencing Center, Washington University School of Medicine)

  • Amber Isak

    (Genome Sequencing Center, Washington University School of Medicine)

  • Andrew VanBrunt

    (Genome Sequencing Center, Washington University School of Medicine)

  • Christine Nguyen

    (Genome Sequencing Center, Washington University School of Medicine)

  • Feiyu Du

    (Genome Sequencing Center, Washington University School of Medicine)

  • Betty Lamar

    (Genome Sequencing Center, Washington University School of Medicine)

  • Laura Courtney

    (Genome Sequencing Center, Washington University School of Medicine)

  • Joelle Kalicki

    (Genome Sequencing Center, Washington University School of Medicine)

  • Philip Ozersky

    (Genome Sequencing Center, Washington University School of Medicine)

  • Lauren Bielicki

    (Genome Sequencing Center, Washington University School of Medicine)

  • Kelsi Scott

    (Genome Sequencing Center, Washington University School of Medicine)

  • Andrea Holmes

    (Genome Sequencing Center, Washington University School of Medicine)

  • Richard Harkins

    (Genome Sequencing Center, Washington University School of Medicine)

  • Anthony Harris

    (Genome Sequencing Center, Washington University School of Medicine)

  • Cynthia Madsen Strong

    (Genome Sequencing Center, Washington University School of Medicine)

  • Shunfang Hou

    (Genome Sequencing Center, Washington University School of Medicine)

  • Chad Tomlinson

    (Genome Sequencing Center, Washington University School of Medicine)

  • Sara Dauphin-Kohlberg

    (Genome Sequencing Center, Washington University School of Medicine)

  • Amy Kozlowicz-Reilly

    (Genome Sequencing Center, Washington University School of Medicine)

  • Shawn Leonard

    (Genome Sequencing Center, Washington University School of Medicine)

  • Theresa Rohlfing

    (Genome Sequencing Center, Washington University School of Medicine)

  • Susan M. Rock

    (Genome Sequencing Center, Washington University School of Medicine)

  • Aye-Mon Tin-Wollam

    (Genome Sequencing Center, Washington University School of Medicine)

  • Amanda Abbott

    (Genome Sequencing Center, Washington University School of Medicine)

  • Patrick Minx

    (Genome Sequencing Center, Washington University School of Medicine)

  • Rachel Maupin

    (Genome Sequencing Center, Washington University School of Medicine)

  • Catrina Strowmatt

    (Genome Sequencing Center, Washington University School of Medicine)

  • Phil Latreille

    (Genome Sequencing Center, Washington University School of Medicine)

  • Nancy Miller

    (Genome Sequencing Center, Washington University School of Medicine)

  • Doug Johnson

    (Genome Sequencing Center, Washington University School of Medicine)

  • Jennifer Murray

    (Genome Sequencing Center, Washington University School of Medicine)

  • Jeffrey P. Woessner

    (Genome Sequencing Center, Washington University School of Medicine)

  • Michael C. Wendl

    (Genome Sequencing Center, Washington University School of Medicine)

  • Shiaw-Pyng Yang

    (Genome Sequencing Center, Washington University School of Medicine)

  • Brian R. Schultz

    (Genome Sequencing Center, Washington University School of Medicine)

  • John W. Wallis

    (Genome Sequencing Center, Washington University School of Medicine)

  • John Spieth

    (Genome Sequencing Center, Washington University School of Medicine)

  • Tamberlyn A. Bieri

    (Genome Sequencing Center, Washington University School of Medicine)

  • Joanne O. Nelson

    (Genome Sequencing Center, Washington University School of Medicine)

  • Nicolas Berkowicz

    (Genome Sequencing Center, Washington University School of Medicine)

  • Patricia E. Wohldmann

    (Genome Sequencing Center, Washington University School of Medicine)

  • Lisa L. Cook

    (Genome Sequencing Center, Washington University School of Medicine)

  • Matthew T. Hickenbotham

    (Genome Sequencing Center, Washington University School of Medicine)

  • James Eldred

    (Genome Sequencing Center, Washington University School of Medicine)

  • Donald Williams

    (Genome Sequencing Center, Washington University School of Medicine)

  • Joseph A. Bedell

    (Genome Sequencing Center, Washington University School of Medicine)

  • Elaine R. Mardis

    (Genome Sequencing Center, Washington University School of Medicine)

  • Sandra W. Clifton

    (Genome Sequencing Center, Washington University School of Medicine)

  • Stephanie L. Chissoe

    (Genome Sequencing Center, Washington University School of Medicine)

  • Marco A. Marra

    (Genome Sequencing Center, Washington University School of Medicine
    Genome Sciences Centre, British Columbia Cancer Agency)

  • Christopher Raymond

    (University of Washington Genome Center)

  • Eric Haugen

    (University of Washington Genome Center)

  • Will Gillett

    (University of Washington Genome Center)

  • Yang Zhou

    (University of Washington Genome Center)

  • Rose James

    (University of Washington Genome Center)

  • Karen Phelps

    (University of Washington Genome Center)

  • Shawn Iadanoto

    (University of Washington Genome Center)

  • Kerry Bubb

    (University of Washington Genome Center)

  • Elizabeth Simms

    (University of Washington Genome Center)

  • Ruth Levy

    (University of Washington Genome Center)

  • James Clendenning

    (University of Washington Genome Center)

  • Rajinder Kaul

    (University of Washington Genome Center)

  • W. James Kent

    (University of California)

  • Terrence S. Furey

    (University of California)

  • Robert A. Baertsch

    (University of California)

  • Michael R. Brent

    (Washington University)

  • Evan Keibler

    (Washington University)

  • Paul Flicek

    (Washington University)

  • Peer Bork

    (EMBL)

  • Mikita Suyama

    (EMBL)

  • Jeffrey A. Bailey

    (Case Western Reserve University School of Medicine and University Hospitals of Cleveland)

  • Matthew E. Portnoy

    (National Institutes of Health, Building 50, Room 5222)

  • David Torrents

    (EMBL)

  • Asif T. Chinwalla

    (Genome Sequencing Center, Washington University School of Medicine)

  • Warren R. Gish

    (Genome Sequencing Center, Washington University School of Medicine)

  • Sean R. Eddy

    (Washington University School of Medicine)

  • John D. McPherson

    (Genome Sequencing Center, Washington University School of Medicine
    Human Genome Sequencing Center)

  • Maynard V. Olson

    (University of Washington Genome Center)

  • Evan E. Eichler

    (Case Western Reserve University School of Medicine and University Hospitals of Cleveland)

  • Eric D. Green

    (National Institutes of Health, Building 50, Room 5222)

  • Robert H. Waterston

    (Genome Sequencing Center, Washington University School of Medicine
    University of Washington)

  • Richard K. Wilson

    (Genome Sequencing Center, Washington University School of Medicine)

Abstract

Human chromosome 7 has historically received prominent attention in the human genetics community, primarily related to the search for the cystic fibrosis gene and the frequent cytogenetic changes associated with various forms of cancer. Here we present more than 153 million base pairs representing 99.4% of the euchromatic sequence of chromosome 7, the first metacentric chromosome completed so far. The sequence has excellent concordance with previously established physical and genetic maps, and it exhibits an unusual amount of segmentally duplicated sequence (8.2%), with marked differences between the two arms. Our initial analyses have identified 1,150 protein-coding genes, 605 of which have been confirmed by complementary DNA sequences, and an additional 941 pseudogenes. Of genes confirmed by transcript sequences, some are polymorphic for mutations that disrupt the reading frame.

Suggested Citation

  • LaDeana W. Hillier & Robert S. Fulton & Lucinda A. Fulton & Tina A. Graves & Kymberlie H. Pepin & Caryn Wagner-McPherson & Dan Layman & Jason Maas & Sara Jaeger & Rebecca Walker & Kristine Wylie & Man, 2003. "The DNA sequence of human chromosome 7," Nature, Nature, vol. 424(6945), pages 157-164, July.
    • Handle: RePEc:nat:nature:v:424:y:2003:i:6945:d:10.1038_nature01782
    DOI: 10.1038/nature01782
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