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Opposite thermosensor in fruitfly and mouse

Author

Listed:
  • Veena Viswanath

    (Genomics Institute of the Novartis Research Foundation)

  • Gina M. Story

    (The Scripps Research Institute)

  • Andrea M. Peier

    (Genomics Institute of the Novartis Research Foundation)

  • Matt J. Petrus

    (Genomics Institute of the Novartis Research Foundation)

  • Van M. Lee

    (Genomics Institute of the Novartis Research Foundation)

  • Sun Wook Hwang

    (The Scripps Research Institute)

  • Ardem Patapoutian

    (Genomics Institute of the Novartis Research Foundation
    The Scripps Research Institute)

  • Tim Jegla

    (Genomics Institute of the Novartis Research Foundation)

Abstract

Several members of the TRP (for transient receptor potential) family of ion channels act as physiological temperature sensors in mammals1,2,3,4,5,6, but it is not known whether the invertebrate TRP subfamilies that are found in the fruitfly Drosophila and the roundworm Caenorhabditis elegans can be directly activated by temperature. Here we show that the Drosophila orthologue of ANKTM1, which is a cold-activated ion channel in mammals, responds to a warming rather than a cooling stimulus. The thermosensing function of these channels is therefore evolutionarily conserved, and they show a surprising flexibility in their response to different temperature ranges.

Suggested Citation

  • Veena Viswanath & Gina M. Story & Andrea M. Peier & Matt J. Petrus & Van M. Lee & Sun Wook Hwang & Ardem Patapoutian & Tim Jegla, 2003. "Opposite thermosensor in fruitfly and mouse," Nature, Nature, vol. 423(6942), pages 822-823, June.
    • Handle: RePEc:nat:nature:v:423:y:2003:i:6942:d:10.1038_423822a
    DOI: 10.1038/423822a
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