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Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis

Author

Listed:
  • Ho-Yon Hwang

    (Massachusetts Institute of Technology)

  • Sara K. Olson

    (University of California, San Diego)

  • Jeffrey D. Esko

    (University of California, San Diego)

  • H. Robert Horvitz

    (Massachusetts Institute of Technology)

Abstract

Defects in glycosaminoglycan biosynthesis disrupt animal development and can cause human disease1,2,3,4. So far much of the focus on glycosaminoglycans has been on heparan sulphate. Mutations in eight squashed vulva (sqv) genes in Caenorhabditis elegans cause defects in cytokinesis during embryogenesis and in vulval morphogenesis during postembryonic development5,6. Seven of the eight sqv genes have been shown to control the biosynthesis of the glycosaminoglycans chondroitin and heparan sulphate6,7,8,9,10,11. Here we present the molecular identification and characterization of the eighth gene, sqv-5. This gene encodes a bifunctional glycosyltransferase that is probably localized to the Golgi apparatus and is responsible for the biosynthesis of chondroitin but not heparan sulphate. Our findings show that chondroitin is crucial for both cytokinesis and morphogenesis during C. elegans development.

Suggested Citation

  • Ho-Yon Hwang & Sara K. Olson & Jeffrey D. Esko & H. Robert Horvitz, 2003. "Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis," Nature, Nature, vol. 423(6938), pages 439-443, May.
    • Handle: RePEc:nat:nature:v:423:y:2003:i:6938:d:10.1038_nature01634
    DOI: 10.1038/nature01634
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