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The genetic basis for skeletal diseases

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  • Elazar Zelzer

    (Harvard Medical School)

  • Bjorn R. Olsen

    (Harvard Medical School)

Abstract

We walk, run, work and play, paying little attention to our bones, their joints and their muscle connections, because the system works. Evolution has refined robust genetic mechanisms for skeletal development and growth that are able to direct the formation of a complex, yet wonderfully adaptable organ system. How is it done? Recent studies of rare genetic diseases have identified many of the critical transcription factors and signalling pathways specifying the normal development of bones, confirming the wisdom of William Harvey when he said: “nature is nowhere accustomed more openly to display her secret mysteries than in cases where she shows traces of her workings apart from the beaten path”.

Suggested Citation

  • Elazar Zelzer & Bjorn R. Olsen, 2003. "The genetic basis for skeletal diseases," Nature, Nature, vol. 423(6937), pages 343-348, May.
    • Handle: RePEc:nat:nature:v:423:y:2003:i:6937:d:10.1038_nature01659
    DOI: 10.1038/nature01659
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