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Insecticide resistance in mosquito vectors

Author

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  • Mylène Weill

    (Institut des Sciences de l'Évolution (UMR 5554), CC 065, Université Montpellier II)

  • Georges Lutfalla

    (Défenses Antivirales et Tumorales (UMR 5124))

  • Knud Mogensen

    (Défenses Antivirales et Tumorales (UMR 5124))

  • Fabrice Chandre

    (IRD/LIN, BP 64501)

  • Arnaud Berthomieu

    (Institut des Sciences de l'Évolution (UMR 5554), CC 065, Université Montpellier II)

  • Claire Berticat

    (Institut des Sciences de l'Évolution (UMR 5554), CC 065, Université Montpellier II)

  • Nicole Pasteur

    (Institut des Sciences de l'Évolution (UMR 5554), CC 065, Université Montpellier II)

  • Alexandre Philips

    (Centre de Recherche en Biochimie des Macromolécules (UPR1086), CNRS)

  • Philippe Fort

    (Centre de Recherche en Biochimie des Macromolécules (UPR1086), CNRS)

  • Michel Raymond

    (Institut des Sciences de l'Évolution (UMR 5554), CC 065, Université Montpellier II)

Abstract

Resistance to insecticides among mosquitoes that act as vectors for malaria (Anopheles gambiae) and West Nile virus (Culex pipiens) emerged more than 25 years ago in Africa, America and Europe; this resistance is frequently due to a loss of sensitivity of the insect's acetylcholinesterase enzyme to organophosphates and carbamates1. Here we show that this insensitivity results from a single amino-acid substitution in the enzyme, which we found in ten highly resistant strains of C. pipiens from tropical (Africa and Caribbean) and temperate (Europe) areas, as well as in one resistant African strain of A. gambiae. Our identification of this mutation may pave the way for designing new insecticides.

Suggested Citation

  • Mylène Weill & Georges Lutfalla & Knud Mogensen & Fabrice Chandre & Arnaud Berthomieu & Claire Berticat & Nicole Pasteur & Alexandre Philips & Philippe Fort & Michel Raymond, 2003. "Insecticide resistance in mosquito vectors," Nature, Nature, vol. 423(6936), pages 136-137, May.
    • Handle: RePEc:nat:nature:v:423:y:2003:i:6936:d:10.1038_423136b
    DOI: 10.1038/423136b
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    Cited by:

    1. Adam M. Finkel & Benjamin D. Trump & Diana Bowman & Andrew Maynard, 2018. "A “solution-focused” comparative risk assessment of conventional and synthetic biology approaches to control mosquitoes carrying the dengue fever virus," Environment Systems and Decisions, Springer, vol. 38(2), pages 177-197, June.
    2. Heong, K.L. & Tan, K.H. & Garcia, C.P.F. & Liu, Z. & Lu, Z., 2013. "Research Methods in Toxicology and Insecticide Resistance Monitoring of Rice Planthoppers," IRRI Books, International Rice Research Institute (IRRI), number 164475.

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