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Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis

Author

Listed:
  • Natalia Ivanova

    (Integrated Genomics)

  • Alexei Sorokin

    (Institut National de la Recherche Agronomique)

  • Iain Anderson

    (Integrated Genomics)

  • Nathalie Galleron

    (Institut National de la Recherche Agronomique)

  • Benjamin Candelon

    (Institut National de la Recherche Agronomique)

  • Vinayak Kapatral

    (Integrated Genomics)

  • Anamitra Bhattacharyya

    (Integrated Genomics)

  • Gary Reznik

    (Life Sciences Operation, Illinois Institute of Technology Research Institute)

  • Natalia Mikhailova

    (Integrated Genomics)

  • Alla Lapidus

    (Integrated Genomics)

  • Lien Chu

    (Integrated Genomics)

  • Michael Mazur

    (Integrated Genomics)

  • Eugene Goltsman

    (Integrated Genomics)

  • Niels Larsen

    (Integrated Genomics)

  • Mark D'Souza

    (Integrated Genomics)

  • Theresa Walunas

    (Integrated Genomics)

  • Yuri Grechkin

    (Integrated Genomics)

  • Gordon Pusch

    (Integrated Genomics)

  • Robert Haselkorn

    (Integrated Genomics)

  • Michael Fonstein

    (Integrated Genomics)

  • S. Dusko Ehrlich

    (Institut National de la Recherche Agronomique)

  • Ross Overbeek

    (Integrated Genomics)

  • Nikos Kyrpides

    (Integrated Genomics)

Abstract

Bacillus cereus is an opportunistic pathogen causing food poisoning manifested by diarrhoeal or emetic syndromes1. It is closely related to the animal and human pathogen Bacillus anthracis and the insect pathogen Bacillus thuringiensis, the former being used as a biological weapon and the latter as a pesticide. B. anthracis and B. thuringiensis are readily distinguished from B. cereus by the presence of plasmid-borne specific toxins (B. anthracis and B. thuringiensis) and capsule (B. anthracis). But phylogenetic studies based on the analysis of chromosomal genes bring controversial results, and it is unclear whether B. cereus, B. anthracis and B. thuringiensis are varieties of the same species2 or different species3,4. Here we report the sequencing and analysis of the type strain B. cereus ATCC 14579. The complete genome sequence of B. cereus ATCC 14579 together with the gapped genome of B. anthracis A20125 enables us to perform comparative analysis, and hence to identify the genes that are conserved between B. cereus and B. anthracis, and the genes that are unique for each species. We use the former to clarify the phylogeny of the cereus group, and the latter to determine plasmid-independent species-specific markers.

Suggested Citation

  • Natalia Ivanova & Alexei Sorokin & Iain Anderson & Nathalie Galleron & Benjamin Candelon & Vinayak Kapatral & Anamitra Bhattacharyya & Gary Reznik & Natalia Mikhailova & Alla Lapidus & Lien Chu & Mich, 2003. "Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis," Nature, Nature, vol. 423(6935), pages 87-91, May.
    • Handle: RePEc:nat:nature:v:423:y:2003:i:6935:d:10.1038_nature01582
    DOI: 10.1038/nature01582
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    Cited by:

    1. Salma Hachfi & Alexandra Brun-Barale & Arnaud Fichant & Patrick Munro & Marie-Paule Nawrot-Esposito & Gregory Michel & Raymond Ruimy & Raphaël Rousset & Mathilde Bonis & Laurent Boyer & Armel Gallet, 2024. "Ingestion of Bacillus cereus spores dampens the immune response to favor bacterial persistence," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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