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Chibby, a nuclear β-catenin-associated antagonist of the Wnt/Wingless pathway

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Listed:
  • Ken-Ichi Takemaru

    (University of Washington School of Medicine)

  • Shinji Yamaguchi

    (Northwestern University)

  • Young Sik Lee

    (Northwestern University)

  • Yang Zhang

    (University of Washington School of Medicine)

  • Richard W. Carthew

    (Northwestern University)

  • Randall T. Moon

    (University of Washington School of Medicine)

Abstract

Inappropriate activation of downstream target genes by the oncoprotein β-catenin is implicated in development of numerous human cancers1,2. β-catenin and its fruitfly counterpart Armadillo act as a coactivator in the canonical Wnt/Wingless pathway by binding to Tcf/Lef transcription factors3,4,5,6. Here we report a conserved nuclear protein, named Chibby, which was identified in a screen for proteins that directly interact with the C-terminal region of β-catenin. In mammalian cultured cells we demonstrate that Chibby inhibits β-catenin-mediated transcriptional activation by competing with Lef-1 to bind to β-catenin. Inhibition of Drosophila Chibby by RNA interference results in segment polarity defects that mimick a wingless gain-of-function phenotype, and overexpression of the wingless target genes engrailed and Ultrabithorax. In addition, epistasis experiments indicate that chibby acts downstream of wingless and upstream of armadillo.

Suggested Citation

  • Ken-Ichi Takemaru & Shinji Yamaguchi & Young Sik Lee & Yang Zhang & Richard W. Carthew & Randall T. Moon, 2003. "Chibby, a nuclear β-catenin-associated antagonist of the Wnt/Wingless pathway," Nature, Nature, vol. 422(6934), pages 905-909, April.
    • Handle: RePEc:nat:nature:v:422:y:2003:i:6934:d:10.1038_nature01570
    DOI: 10.1038/nature01570
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