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The genome sequence of the filamentous fungus Neurospora crassa

Author

Listed:
  • James E. Galagan

    (Whitehead Institute Center for Genome Research)

  • Sarah E. Calvo

    (Whitehead Institute Center for Genome Research)

  • Katherine A. Borkovich

    (University of California)

  • Eric U. Selker

    (University of Oregon)

  • Nick D. Read

    (University of Edinburgh)

  • David Jaffe

    (Whitehead Institute Center for Genome Research)

  • William FitzHugh

    (Celera Genomics)

  • Li-Jun Ma

    (Whitehead Institute Center for Genome Research)

  • Serge Smirnov

    (Whitehead Institute Center for Genome Research)

  • Seth Purcell

    (Whitehead Institute Center for Genome Research)

  • Bushra Rehman

    (Whitehead Institute Center for Genome Research)

  • Timothy Elkins

    (Whitehead Institute Center for Genome Research)

  • Reinhard Engels

    (Whitehead Institute Center for Genome Research)

  • Shunguang Wang

    (Whitehead Institute Center for Genome Research)

  • Cydney B. Nielsen

    (Whitehead Institute Center for Genome Research)

  • Jonathan Butler

    (Whitehead Institute Center for Genome Research)

  • Matthew Endrizzi

    (Whitehead Institute Center for Genome Research)

  • Dayong Qui

    (Whitehead Institute Center for Genome Research)

  • Peter Ianakiev

    (Whitehead Institute Center for Genome Research)

  • Deborah Bell-Pedersen

    (Texas A & M University)

  • Mary Anne Nelson

    (University of New Mexico)

  • Margaret Werner-Washburne

    (University of New Mexico)

  • Claude P. Selitrennikoff

    (University of Colorado Health Sciences Center)

  • John A. Kinsey

    (University of Kansas Medical School)

  • Edward L. Braun

    (University of Florida)

  • Alex Zelter

    (University of Edinburgh
    The Hebrew University of Jerusalem)

  • Ulrich Schulte

    (Institute of Biochemistry, Heinrich Heine University)

  • Gregory O. Kothe

    (University of Oregon)

  • Gregory Jedd

    (Rockefeller University)

  • Werner Mewes

    (Technical University of Munich, Wissenschaftzentrum Weihenstephan
    Institute for Bioinformatics (MIPS), GSF-National Research Center for Environment and Health)

  • Chuck Staben

    (University of Kentucky)

  • Edward Marcotte

    (The University of Texas at Austin)

  • David Greenberg

    (The Institute for Genomic Research)

  • Alice Roy

    (Whitehead Institute Center for Genome Research)

  • Karen Foley

    (Whitehead Institute Center for Genome Research)

  • Jerome Naylor

    (Whitehead Institute Center for Genome Research)

  • Nicole Stange-Thomann

    (Whitehead Institute Center for Genome Research)

  • Robert Barrett

    (Whitehead Institute Center for Genome Research)

  • Sante Gnerre

    (Whitehead Institute Center for Genome Research)

  • Michael Kamal

    (Whitehead Institute Center for Genome Research)

  • Manolis Kamvysselis

    (Whitehead Institute Center for Genome Research)

  • Evan Mauceli

    (Whitehead Institute Center for Genome Research)

  • Cord Bielke

    (Technical University of Munich, Wissenschaftzentrum Weihenstephan)

  • Stephen Rudd

    (Institute for Bioinformatics (MIPS), GSF-National Research Center for Environment and Health)

  • Dmitrij Frishman

    (Institute for Bioinformatics (MIPS), GSF-National Research Center for Environment and Health)

  • Svetlana Krystofova

    (University of California)

  • Carolyn Rasmussen

    (University of California)

  • Robert L. Metzenberg

    (University of California)

  • David D. Perkins

    (University of California)

  • Scott Kroken

    (University of California)

  • Carlo Cogoni

    (Universita' di Roma La Sapienza)

  • Giuseppe Macino

    (Universita' di Roma La Sapienza)

  • David Catcheside

    (Flinders University)

  • Weixi Li

    (University of Kentucky)

  • Robert J. Pratt

    (Texas A & M University)

  • Stephen A. Osmani

    (The Ohio State University)

  • Colin P. C. DeSouza

    (The Ohio State University)

  • Louise Glass

    (University of California)

  • Marc J. Orbach

    (University of Arizona)

  • J. Andrew Berglund

    (University of Oregon)

  • Rodger Voelker

    (University of Oregon)

  • Oded Yarden

    (The Hebrew University of Jerusalem)

  • Michael Plamann

    (University of Missouri-Kansas City)

  • Stephan Seiler

    (University of Missouri-Kansas City)

  • Jay Dunlap

    (Dartmouth Medical School)

  • Alan Radford

    (Leeds University)

  • Rodolfo Aramayo

    (Texas A & M University)

  • Donald O. Natvig

    (University of New Mexico)

  • Lisa A. Alex

    (California State Polytechnic University Pomona)

  • Gertrud Mannhaupt

    (Technical University of Munich, Wissenschaftzentrum Weihenstephan)

  • Daniel J. Ebbole

    (Texas A & M University)

  • Michael Freitag

    (University of Oregon)

  • Ian Paulsen

    (The Institute for Genomic Research)

  • Matthew S. Sachs

    (Oregon Health and Science University)

  • Eric S. Lander

    (Whitehead Institute Center for Genome Research
    MIT)

  • Chad Nusbaum

    (Whitehead Institute Center for Genome Research)

  • Bruce Birren

    (Whitehead Institute Center for Genome Research)

Abstract

Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. The approximately 40-megabase genome encodes about 10,000 protein-coding genes—more than twice as many as in the fission yeast Schizosaccharomyces pombe and only about 25% fewer than in the fruitfly Drosophila melanogaster. Analysis of the gene set yields insights into unexpected aspects of Neurospora biology including the identification of genes potentially associated with red light photobiology, genes implicated in secondary metabolism, and important differences in Ca2+ signalling as compared with plants and animals. Neurospora possesses the widest array of genome defence mechanisms known for any eukaryotic organism, including a process unique to fungi called repeat-induced point mutation (RIP). Genome analysis suggests that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.

Suggested Citation

  • James E. Galagan & Sarah E. Calvo & Katherine A. Borkovich & Eric U. Selker & Nick D. Read & David Jaffe & William FitzHugh & Li-Jun Ma & Serge Smirnov & Seth Purcell & Bushra Rehman & Timothy Elkins , 2003. "The genome sequence of the filamentous fungus Neurospora crassa," Nature, Nature, vol. 422(6934), pages 859-868, April.
    • Handle: RePEc:nat:nature:v:422:y:2003:i:6934:d:10.1038_nature01554
    DOI: 10.1038/nature01554
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