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Regulated portals of entry into the cell

Author

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  • Sean D. Conner

    (The Scripps Research Institute)

  • Sandra L. Schmid

    (The Scripps Research Institute)

Abstract

The plasma membrane is the interface between cells and their harsh environment. Uptake of nutrients and all communication among cells and between cells and their environment occurs through this interface. ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane. It controls entry into the cell and has a crucial role in development, the immune response, neurotransmission, intercellular communication, signal transduction, and cellular and organismal homeostasis. As the complexity of molecular interactions governing endocytosis are revealed, it has become increasingly clear that it is tightly coordinated and coupled with overall cell physiology and thus, must be viewed in a broader context than simple vesicular trafficking.

Suggested Citation

  • Sean D. Conner & Sandra L. Schmid, 2003. "Regulated portals of entry into the cell," Nature, Nature, vol. 422(6927), pages 37-44, March.
    • Handle: RePEc:nat:nature:v:422:y:2003:i:6927:d:10.1038_nature01451
    DOI: 10.1038/nature01451
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    Cited by:

    1. Samsuzzoha Mondal & Karthik Narayan & Samuel Botterbusch & Imania Powers & Jason Zheng & Honey Priya James & Rui Jin & Tobias Baumgart, 2022. "Multivalent interactions between molecular components involved in fast endophilin mediated endocytosis drive protein phase separation," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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