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Yeast genome duplication was followed by asynchronous differentiation of duplicated genes

Author

Listed:
  • Rikke B. LangkjAEr

    (BioCentrum-DTU, Technical University of Denmark, Building 301)

  • Paul F. Cliften

    (Washington University School of Medicine)

  • Mark Johnston

    (Washington University School of Medicine)

  • Jure Piškur

    (BioCentrum-DTU, Technical University of Denmark, Building 301)

Abstract

Gene redundancy has been observed in yeast, plant and human genomes, and is thought to be a consequence of whole-genome duplications1,2,3. Baker's yeast, Saccharomyces cerevisiae, contains several hundred duplicated genes1. Duplication(s) could have occurred before or after a given speciation. To understand the evolution of the yeast genome, we analysed orthologues of some of these genes in several related yeast species. On the basis of the inferred phylogeny of each set of genes, we were able to deduce whether the gene duplicated and/or specialized before or after the divergence of two yeast lineages. Here we show that the gene duplications might have occurred as a single event, and that it probably took place before the Saccharomyces and Kluyveromyces lineages diverged from each other. Further evolution of each duplicated gene pair—such as specialization or differentiation of the two copies, or deletion of a single copy—has taken place independently throughout the evolution of these species.

Suggested Citation

  • Rikke B. LangkjAEr & Paul F. Cliften & Mark Johnston & Jure Piškur, 2003. "Yeast genome duplication was followed by asynchronous differentiation of duplicated genes," Nature, Nature, vol. 421(6925), pages 848-852, February.
    • Handle: RePEc:nat:nature:v:421:y:2003:i:6925:d:10.1038_nature01419
    DOI: 10.1038/nature01419
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    Cited by:

    1. Mustafa Malik Ghulam & Mathieu Catala & Gaspard Reulet & Michelle S. Scott & Sherif Abou Elela, 2022. "Duplicated ribosomal protein paralogs promote alternative translation and drug resistance," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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