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Direct activation of RNA polymerase III transcription by c-Myc

Author

Listed:
  • Natividad Gomez-Roman

    (University of Glasgow)

  • Carla Grandori

    (Division of Basic Sciences, Fred Hutchinson Cancer Research Center)

  • Robert N. Eisenman

    (Division of Basic Sciences, Fred Hutchinson Cancer Research Center)

  • Robert J. White

    (University of Glasgow)

Abstract

The proto-oncogene product c-Myc has a direct role in both metazoan cell growth and division1,2,3,4. RNA polymerase III (pol III) is involved in the generation of transfer RNA and 5S ribosomal RNA, and these molecules must be produced in bulk to meet the need for protein synthesis in growing cells5. We demonstrate here that c-Myc binds to TFIIIB, a pol III-specific general transcription factor, and directly activates pol III transcription. Chromatin immunoprecipitation reveals that endogenous c-Myc is present at tRNA and 5S rRNA genes in cultured mammalian cells. These results suggest that activation of pol III may have a role in the ability of c-Myc to stimulate cell growth.

Suggested Citation

  • Natividad Gomez-Roman & Carla Grandori & Robert N. Eisenman & Robert J. White, 2003. "Direct activation of RNA polymerase III transcription by c-Myc," Nature, Nature, vol. 421(6920), pages 290-294, January.
    • Handle: RePEc:nat:nature:v:421:y:2003:i:6920:d:10.1038_nature01327
    DOI: 10.1038/nature01327
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    Cited by:

    1. Joy Edwards-Hicks & Huizhong Su & Maurizio Mangolini & Kubra K. Yoneten & Jimi Wills & Giovanny Rodriguez-Blanco & Christine Young & Kevin Cho & Heather Barker & Morwenna Muir & Ania Naila Guerrieri &, 2022. "MYC sensitises cells to apoptosis by driving energetic demand," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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