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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Author

Listed:
  • Martin Holzenberger

    (Hôpital Saint-Antoine)

  • Joëlle Dupont

    (Institut National de la Recherche Agronomique)

  • Bertrand Ducos

    (Hôpital Saint-Antoine)

  • Patricia Leneuve

    (Hôpital Saint-Antoine)

  • Alain Géloën

    (Institut National de la Santé et de la Recherche Médicale U352, INSA)

  • Patrick C. Even

    (Institut National de la Recherche Agronomique, INA P-G)

  • Pascale Cervera

    (Hôpital Saint-Antoine)

  • Yves Le Bouc

    (Hôpital Saint-Antoine)

Abstract

Studies in invertebrates have led to the identification of a number of genes that regulate lifespan, some of which encode components of the insulin or insulin-like signalling pathways1,2,3. Examples include the related tyrosine kinase receptors InR (Drosophila melanogaster) and DAF-2 (Caenorhabditis elegans) that are homologues of the mammalian insulin-like growth factor type 1 receptor (IGF-1R). To investigate whether IGF-1R also controls longevity in mammals, we inactivated the IGF-1R gene in mice (Igf1r). Here, using heterozygous knockout mice because null mutants are not viable, we report that Igf1r+/- mice live on average 26% longer than their wild-type littermates (P

Suggested Citation

  • Martin Holzenberger & Joëlle Dupont & Bertrand Ducos & Patricia Leneuve & Alain Géloën & Patrick C. Even & Pascale Cervera & Yves Le Bouc, 2003. "IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice," Nature, Nature, vol. 421(6919), pages 182-187, January.
    • Handle: RePEc:nat:nature:v:421:y:2003:i:6919:d:10.1038_nature01298
    DOI: 10.1038/nature01298
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    Cited by:

    1. Wang Yuan & Yi M. Weaver & Svetlana Earnest & Clinton A. Taylor & Melanie H. Cobb & Benjamin P. Weaver, 2023. "Modulating p38 MAPK signaling by proteostasis mechanisms supports tissue integrity during growth and aging," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Yan-Ping Zhang & Wen-Hong Zhang & Pan Zhang & Qi Li & Yue Sun & Jia-Wen Wang & Shaobing O. Zhang & Tao Cai & Cheng Zhan & Meng-Qiu Dong, 2022. "Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Thomas Agius & Raffaella Emsley & Arnaud Lyon & Michael R. MacArthur & Kevin Kiesworo & Anna Faivre & Louis Stavart & Martine Lambelet & David Legouis & Sophie Seigneux & Déla Golshayan & Francois Laz, 2024. "Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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