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Chemical copying of connectivity

Author

Listed:
  • Lars Henning Eckardt

    (Lehrstuhl für Bioorganische Chemie, Ruhr-Universität Bochum)

  • Kai Naumann

    (Lehrstuhl für Bioorganische Chemie, Ruhr-Universität Bochum)

  • Wolf Matthias Pankau

    (Lehrstuhl für Bioorganische Chemie, Ruhr-Universität Bochum)

  • Michael Rein

    (Lehrstuhl für Bioorganische Chemie, Ruhr-Universität Bochum)

  • Markus Schweitzer

    (Nanogen Recognomics, Industriepark Hoechst)

  • Norbert Windhab

    (Nanogen Recognomics, Industriepark Hoechst)

  • Günter von Kiedrowski

    (Lehrstuhl für Bioorganische Chemie, Ruhr-Universität Bochum)

Abstract

Three-dimensional DNA nanoscaffolds such as supramolecular tetrahedra can self-assemble from tris-oligonucleotidyls — synthetic three-armed building blocks in which three identical or non-identical short DNA sequences are connected by a tris-linking backbone1,2. Here we show that the connectivity information contained in these building blocks can be copied by using template-directed tris-linking. This finding is a crucial step towards the replication of nanoarchitectures that are based on tris-oligonucleotidyls and to the realization of artificially self-replicating systems on a nanometre scale.

Suggested Citation

  • Lars Henning Eckardt & Kai Naumann & Wolf Matthias Pankau & Michael Rein & Markus Schweitzer & Norbert Windhab & Günter von Kiedrowski, 2002. "Chemical copying of connectivity," Nature, Nature, vol. 420(6913), pages 286-286, November.
    • Handle: RePEc:nat:nature:v:420:y:2002:i:6913:d:10.1038_420286a
    DOI: 10.1038/420286a
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