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Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli

Author

Listed:
  • Mario de Bono

    (Programs in Developmental Biology, Neuroscience, and Genetics, Departments of Anatomy and Biochemistry & Biophysics, UCSF
    MRC Laboratory of Molecular Biology)

  • David M. Tobin

    (Programs in Developmental Biology, Neuroscience, and Genetics, Departments of Anatomy and Biochemistry & Biophysics, UCSF)

  • M. Wayne Davis

    (University of Texas Southwestern Medical Center
    University of Utah)

  • Leon Avery

    (University of Texas Southwestern Medical Center)

  • Cornelia I. Bargmann

    (Programs in Developmental Biology, Neuroscience, and Genetics, Departments of Anatomy and Biochemistry & Biophysics, UCSF)

Abstract

Natural Caenorhabditis elegans isolates exhibit either social or solitary feeding on bacteria. We show here that social feeding is induced by nociceptive neurons that detect adverse or stressful conditions. Ablation of the nociceptive neurons ASH and ADL transforms social animals into solitary feeders. Social feeding is probably due to the sensation of noxious chemicals by ASH and ADL neurons; it requires the genes ocr-2 and osm-9, which encode TRP-related transduction channels, and odr-4 and odr-8, which are required to localize sensory chemoreceptors to cilia. Other sensory neurons may suppress social feeding, as social feeding in ocr-2 and odr-4 mutants is restored by mutations in osm-3, a gene required for the development of 26 ciliated sensory neurons. Our data suggest a model for regulation of social feeding by opposing sensory inputs: aversive inputs to nociceptive neurons promote social feeding, whereas antagonistic inputs from neurons that express osm-3 inhibit aggregation.

Suggested Citation

  • Mario de Bono & David M. Tobin & M. Wayne Davis & Leon Avery & Cornelia I. Bargmann, 2002. "Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli," Nature, Nature, vol. 419(6910), pages 899-903, October.
    • Handle: RePEc:nat:nature:v:419:y:2002:i:6910:d:10.1038_nature01169
    DOI: 10.1038/nature01169
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    Cited by:

    1. Laurens Broeckx & Lotte Frooninckx & Laurien Slegers & Siebe Berrens & Isabelle Noyens & Sarah Goossens & Geert Verheyen & Ann Wuyts & Sabine Van Miert, 2021. "Growth of Black Soldier Fly Larvae Reared on Organic Side-Streams," Sustainability, MDPI, vol. 13(23), pages 1-20, November.
    2. Mara H. Cowen & Dustin Haskell & Kristi Zoga & Kirthi C. Reddy & Sreekanth H. Chalasani & Michael P. Hart, 2024. "Conserved autism-associated genes tune social feeding behavior in C. elegans," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Leon Avery & Brian Ingalls & Catherine Dumur & Alexander Artyukhin, 2021. "A Keller-Segel model for C elegans L1 aggregation," PLOS Computational Biology, Public Library of Science, vol. 17(7), pages 1-25, July.

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