IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v419y2002i6910d10.1038_nature01169.html
   My bibliography  Save this article

Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli

Author

Listed:
  • Mario de Bono

    (Programs in Developmental Biology, Neuroscience, and Genetics, Departments of Anatomy and Biochemistry & Biophysics, UCSF
    MRC Laboratory of Molecular Biology)

  • David M. Tobin

    (Programs in Developmental Biology, Neuroscience, and Genetics, Departments of Anatomy and Biochemistry & Biophysics, UCSF)

  • M. Wayne Davis

    (University of Texas Southwestern Medical Center
    University of Utah)

  • Leon Avery

    (University of Texas Southwestern Medical Center)

  • Cornelia I. Bargmann

    (Programs in Developmental Biology, Neuroscience, and Genetics, Departments of Anatomy and Biochemistry & Biophysics, UCSF)

Abstract

Natural Caenorhabditis elegans isolates exhibit either social or solitary feeding on bacteria. We show here that social feeding is induced by nociceptive neurons that detect adverse or stressful conditions. Ablation of the nociceptive neurons ASH and ADL transforms social animals into solitary feeders. Social feeding is probably due to the sensation of noxious chemicals by ASH and ADL neurons; it requires the genes ocr-2 and osm-9, which encode TRP-related transduction channels, and odr-4 and odr-8, which are required to localize sensory chemoreceptors to cilia. Other sensory neurons may suppress social feeding, as social feeding in ocr-2 and odr-4 mutants is restored by mutations in osm-3, a gene required for the development of 26 ciliated sensory neurons. Our data suggest a model for regulation of social feeding by opposing sensory inputs: aversive inputs to nociceptive neurons promote social feeding, whereas antagonistic inputs from neurons that express osm-3 inhibit aggregation.

Suggested Citation

  • Mario de Bono & David M. Tobin & M. Wayne Davis & Leon Avery & Cornelia I. Bargmann, 2002. "Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli," Nature, Nature, vol. 419(6910), pages 899-903, October.
  • Handle: RePEc:nat:nature:v:419:y:2002:i:6910:d:10.1038_nature01169
    DOI: 10.1038/nature01169
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature01169
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature01169?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Laurens Broeckx & Lotte Frooninckx & Laurien Slegers & Siebe Berrens & Isabelle Noyens & Sarah Goossens & Geert Verheyen & Ann Wuyts & Sabine Van Miert, 2021. "Growth of Black Soldier Fly Larvae Reared on Organic Side-Streams," Sustainability, MDPI, vol. 13(23), pages 1-20, November.
    2. Leon Avery & Brian Ingalls & Catherine Dumur & Alexander Artyukhin, 2021. "A Keller-Segel model for C elegans L1 aggregation," PLOS Computational Biology, Public Library of Science, vol. 17(7), pages 1-25, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:419:y:2002:i:6910:d:10.1038_nature01169. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.