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Progenitor cell maintenance requires numb and numblike during mouse neurogenesis

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Listed:
  • Petur H. Petersen

    (Yale University)

  • Kaiyong Zou

    (Yale University)

  • Joseph K. Hwang

    (Yale University)

  • Yuh Nung Jan

    (University of California)

  • Weimin Zhong

    (Yale University)

Abstract

Neurons in most regions of the mammalian nervous system are generated over an extended period of time during development. Maintaining sufficient numbers of progenitors over the course of neurogenesis is essential to ensure that neural cells are produced in correct numbers and diverse types1,2,3. The underlying molecular mechanisms, like those governing stem-cell self-renewal in general, remain poorly understood. We report here that mouse numb and numblike (Nbl)4,5,6, two highly conserved homologues of Drosophila numb7,8, play redundant but critical roles in maintaining neural progenitor cells during embryogenesis, by allowing their progenies to choose progenitor over neuronal fates. In Nbl mutant embryos also conditionally mutant for mouse numb in the nervous system, early neurons emerge in the expected spatial and temporal pattern, but at the expense of progenitor cells, leading to a nearly complete depletion of dividing cells shortly after the onset of neurogenesis. Our findings show that a shared molecular mechanism, with mouse Numb and Nbl as key components, governs the self-renewal of all neural progenitor cells, regardless of their lineage or regional identities.

Suggested Citation

  • Petur H. Petersen & Kaiyong Zou & Joseph K. Hwang & Yuh Nung Jan & Weimin Zhong, 2002. "Progenitor cell maintenance requires numb and numblike during mouse neurogenesis," Nature, Nature, vol. 419(6910), pages 929-934, October.
    • Handle: RePEc:nat:nature:v:419:y:2002:i:6910:d:10.1038_nature01124
    DOI: 10.1038/nature01124
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    Cited by:

    1. Michelle M. Kameda-Smith & Helen Zhu & En-Ching Luo & Yujin Suk & Agata Xella & Brian Yee & Chirayu Chokshi & Sansi Xing & Frederick Tan & Raymond G. Fox & Ashley A. Adile & David Bakhshinyan & Kevin , 2022. "Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Xiaoliang Liu & Patricia T. Yam & Sabrina Schlienger & Eva Cai & Jingyi Zhang & Wei-Ju Chen & Oscar Torres Gutierrez & Vanesa Jimenez Amilburu & Vasanth Ramamurthy & Alice Y. Ting & Tess C. Branon & M, 2024. "Numb positively regulates Hedgehog signaling at the ciliary pocket," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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