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Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

Author

Listed:
  • Jane M. Carlton

    (The Institute for Genomic Research)

  • Samuel V. Angiuoli

    (The Institute for Genomic Research)

  • Bernard B. Suh

    (The Institute for Genomic Research)

  • Taco W. Kooij

    (Leiden University Medical Centre)

  • Mihaela Pertea

    (The Institute for Genomic Research)

  • Joana C. Silva

    (The Institute for Genomic Research)

  • Maria D. Ermolaeva

    (The Institute for Genomic Research)

  • Jonathan E. Allen

    (The Institute for Genomic Research)

  • Jeremy D. Selengut

    (The Institute for Genomic Research)

  • Hean L. Koo

    (The Institute for Genomic Research)

  • Jeremy D. Peterson

    (The Institute for Genomic Research)

  • Mihai Pop

    (The Institute for Genomic Research)

  • Daniel S. Kosack

    (The Institute for Genomic Research)

  • Martin F. Shumway

    (The Institute for Genomic Research)

  • Shelby L. Bidwell

    (The Institute for Genomic Research)

  • Shamira J. Shallom

    (The Institute for Genomic Research)

  • Susan E. van Aken

    (The Institute for Genomic Research)

  • Steven B. Riedmuller

    (The Institute for Genomic Research)

  • Tamara V. Feldblyum

    (The Institute for Genomic Research)

  • Jennifer K. Cho

    (The Institute for Genomic Research
    Genentech)

  • John Quackenbush

    (The Institute for Genomic Research)

  • Martha Sedegah

    (Naval Medical Research Center, Malaria Program (IDD))

  • Azadeh Shoaibi

    (The Institute for Genomic Research)

  • Leda M. Cummings

    (The Institute for Genomic Research
    National Institutes of Health)

  • Laurence Florens

    (The Scripps Research Institute)

  • John R. Yates

    (The Scripps Research Institute)

  • J. Dale Raine

    (Imperial College of Science, Technology & Medicine)

  • Robert E. Sinden

    (Imperial College of Science, Technology & Medicine)

  • Michael A. Harris

    (Celera Genomics)

  • Deirdre A. Cunningham

    (National Institute for Medical Research)

  • Peter R. Preiser

    (National Institute for Medical Research)

  • Lawrence W. Bergman

    (Drexel University College of Medicine)

  • Akhil B. Vaidya

    (Drexel University College of Medicine)

  • Leo H. van Lin

    (Leiden University Medical Centre)

  • Chris J. Janse

    (Leiden University Medical Centre)

  • Andrew P. Waters

    (Leiden University Medical Centre)

  • Hamilton O. Smith

    (Celera Genomics)

  • Owen R. White

    (The Institute for Genomic Research)

  • Steven L. Salzberg

    (The Institute for Genomic Research)

  • J. Craig Venter

    (The Center for the Advancement of Genomics)

  • Claire M. Fraser

    (The Institute for Genomic Research)

  • Stephen L. Hoffman

    (Naval Medical Research Center, Malaria Program (IDD)
    Sanaria)

  • Malcolm J. Gardner

    (The Institute for Genomic Research)

  • Daniel J. Carucci

    (Naval Medical Research Center, Malaria Program (IDD))

Abstract

Species of malaria parasite that infect rodents have long been used as models for malaria disease research. Here we report the whole-genome shotgun sequence of one species, Plasmodium yoelii yoelii, and comparative studies with the genome of the human malaria parasite Plasmodium falciparum clone 3D7. A synteny map of 2,212 P. y. yoelii contiguous DNA sequences (contigs) aligned to 14 P. falciparum chromosomes reveals marked conservation of gene synteny within the body of each chromosome. Of about 5,300 P. falciparum genes, more than 3,300 P. y. yoelii orthologues of predominantly metabolic function were identified. Over 800 copies of a variant antigen gene located in subtelomeric regions were found. This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease.

Suggested Citation

  • Jane M. Carlton & Samuel V. Angiuoli & Bernard B. Suh & Taco W. Kooij & Mihaela Pertea & Joana C. Silva & Maria D. Ermolaeva & Jonathan E. Allen & Jeremy D. Selengut & Hean L. Koo & Jeremy D. Peterson, 2002. "Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii," Nature, Nature, vol. 419(6906), pages 512-519, October.
    • Handle: RePEc:nat:nature:v:419:y:2002:i:6906:d:10.1038_nature01099
    DOI: 10.1038/nature01099
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    Cited by:

    1. Mohammed Y. Refai & Aala A. Abulfaraj & Israa J. Hakeem & Nehad A. Shaer & Mashael D. Alqahtani & Maryam M. Alomran & Nahaa M. Alotaibi & Hana S. Sonbol & Abdulrahman M. Alhashimi & Nouf S. Al-Abbas &, 2023. "Rhizobiome Signature and Its Alteration Due to Watering in the Wild Plant Moringa oleifera," Sustainability, MDPI, vol. 15(3), pages 1-25, February.
    2. Manal A. Tashkandi & Rewaa S. Jalal & Lina Baz & Mohammed Y. Refai & Ashwag Shami & Ruba Abdulrahman Ashy & Haneen W. Abuauf & Fatimah M. Alshehrei & Fawzia A. Alshubaily & Aminah A. Barqawi & Sahar A, 2022. "Functional Interpretation of Cross-Talking Pathways with Emphasis on Amino Acid Metabolism in Rhizosphere Microbiome of the Wild Plant Moringa oleifera," Agriculture, MDPI, vol. 12(11), pages 1-22, October.

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