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Sequence of Plasmodium falciparum chromosomes 1, 3–9 and 13

Author

Listed:
  • N. Hall

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • A. Pain

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • M. Berriman

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • C. Churcher

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • B. Harris

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • D. Harris

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • K. Mungall

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • S. Bowman

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus
    Syngenta, Jealott's Hill International Research Centre)

  • R. Atkin

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • S. Baker

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • A. Barron

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • K. Brooks

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • C. O. Buckee

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • C. Burrows

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • I. Cherevach

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • C. Chillingworth

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • T. Chillingworth

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • Z. Christodoulou

    (University of Oxford, John Radcliffe Hospital)

  • L. Clark

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • R. Clark

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • C. Corton

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • A. Cronin

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • R. Davies

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • P. Davis

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • P. Dear

    (MRC Laboratory of Molecular Biology)

  • F. Dearden

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • J. Doggett

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • T. Feltwell

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • A. Goble

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • I. Goodhead

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • R. Gwilliam

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • N. Hamlin

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • Z. Hance

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • D. Harper

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • H. Hauser

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • T. Hornsby

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • S. Holroyd

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • P. Horrocks

    (University of Oxford, John Radcliffe Hospital)

  • S. Humphray

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • K. Jagels

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • K. D. James

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • D. Johnson

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • A. Kerhornou

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • A. Knights

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • B. Konfortov

    (MRC Laboratory of Molecular Biology)

  • S. Kyes

    (University of Oxford, John Radcliffe Hospital)

  • N. Larke

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • D. Lawson

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • N. Lennard

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • A. Line

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • M. Maddison

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • J. McLean

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • P. Mooney

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • S. Moule

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • L. Murphy

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • K. Oliver

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • D. Ormond

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • C. Price

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • M. A. Quail

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • E. Rabbinowitsch

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • M.-A. Rajandream

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • S. Rutter

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • K. M. Rutherford

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • M. Sanders

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • M. Simmonds

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • K. Seeger

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • S. Sharp

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • R. Smith

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • R. Squares

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • S. Squares

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • K. Stevens

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • K. Taylor

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • A. Tivey

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • L. Unwin

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • S. Whitehead

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • J. Woodward

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • J. E. Sulston

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

  • A. Craig

    (University of Oxford, John Radcliffe Hospital
    Liverpool School of Tropical Medicine, Pembroke Place)

  • C. Newbold

    (University of Oxford, John Radcliffe Hospital)

  • B. G. Barrell

    (The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus)

Abstract

Since the sequencing of the first two chromosomes of the malaria parasite, Plasmodium falciparum1,2, there has been a concerted effort to sequence and assemble the entire genome of this organism. Here we report the sequence of chromosomes 1, 3–9 and 13 of P. falciparum clone 3D7—these chromosomes account for approximately 55% of the total genome. We describe the methods used to map, sequence and annotate these chromosomes. By comparing our assemblies with the optical map, we indicate the completeness of the resulting sequence. During annotation, we assign Gene Ontology terms to the predicted gene products, and observe clustering of some malaria-specific terms to specific chromosomes. We identify a highly conserved sequence element found in the intergenic region of internal var genes that is not associated with their telomeric counterparts.

Suggested Citation

  • N. Hall & A. Pain & M. Berriman & C. Churcher & B. Harris & D. Harris & K. Mungall & S. Bowman & R. Atkin & S. Baker & A. Barron & K. Brooks & C. O. Buckee & C. Burrows & I. Cherevach & C. Chillingwor, 2002. "Sequence of Plasmodium falciparum chromosomes 1, 3–9 and 13," Nature, Nature, vol. 419(6906), pages 527-531, October.
    • Handle: RePEc:nat:nature:v:419:y:2002:i:6906:d:10.1038_nature01095
    DOI: 10.1038/nature01095
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