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Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases

Author

Listed:
  • Wun Chey Sin

    (Cold Spring Harbor Laboratory)

  • Kurt Haas

    (Cold Spring Harbor Laboratory)

  • Edward S. Ruthazer

    (Cold Spring Harbor Laboratory)

  • Hollis T. Cline

    (Cold Spring Harbor Laboratory)

Abstract

Previous studies suggest that neuronal activity may guide the development of synaptic connections in the central nervous system through mechanisms involving glutamate receptors and GTPase-dependent modulation of the actin cytoskeleton1,2,3,4,5,6,7. Here we demonstrate by in vivo time-lapse imaging of optic tectal cells in Xenopus laevis tadpoles that enhanced visual activity driven by a light stimulus promotes dendritic arbor growth. The stimulus-induced dendritic arbor growth requires glutamate-receptor-mediated synaptic transmission, decreased RhoA activity and increased Rac and Cdc42 activity. The results delineate a role for Rho GTPases in the structural plasticity driven by visual stimulation in vivo.

Suggested Citation

  • Wun Chey Sin & Kurt Haas & Edward S. Ruthazer & Hollis T. Cline, 2002. "Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases," Nature, Nature, vol. 419(6906), pages 475-480, October.
    • Handle: RePEc:nat:nature:v:419:y:2002:i:6906:d:10.1038_nature00987
    DOI: 10.1038/nature00987
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    Cited by:

    1. Yuan Liao & Lifeng Ma & Qile Guo & Weigao E & Xing Fang & Lei Yang & Fanwei Ruan & Jingjing Wang & Peijing Zhang & Zhongyi Sun & Haide Chen & Zhongliang Lin & Xueyi Wang & Xinru Wang & Huiyu Sun & Xiu, 2022. "Cell landscape of larval and adult Xenopus laevis at single-cell resolution," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Xu-Fei Du & Fu-Ning Li & Xiao-Lan Peng & Bing Xu & Yu Zhang & Guang Li & Taole Liu & Ying Li & Han Wang & Jun Yan & Jiu-Lin Du, 2023. "Circadian regulation of developmental synaptogenesis via the hypocretinergic system," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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