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RGM is a repulsive guidance molecule for retinal axons

Author

Listed:
  • Philippe P. Monnier

    (Migragen AG)

  • Ana Sierra

    (Migragen AG)

  • Paolo Macchi

    (Max-Planck-Institut für Entwicklungsbiologie)

  • Lutz Deitinghoff

    (Migragen AG)

  • Jens S. Andersen

    (University of Southern Denmark)

  • Matthias Mann

    (University of Southern Denmark)

  • Manuela Flad

    (DeveloGen AG)

  • Martin R. Hornberger

    (Migragen AG)

  • Bernd Stahl

    (Migragen AG)

  • Friedrich Bonhoeffer

    (Max-Planck-Institut für Entwicklungsbiologie)

  • Bernhard K. Mueller

    (Migragen AG)

Abstract

Axons rely on guidance cues to reach remote targets during nervous system development1. A well-studied model system for axon guidance is the retinotectal projection. The retina can be divided into halves; the nasal half, next to the nose, and the temporal half. A subset of retinal axons, those from the temporal half, is guided by repulsive cues expressed in a graded fashion in the optic tectum2,3, part of the midbrain. Here we report the cloning and functional characterization of a membrane-associated glycoprotein, which we call RGM (repulsive guidance molecule). This molecule shares no sequence homology with known guidance cues, and its messenger RNA is distributed in a gradient with increasing concentration from the anterior to posterior pole of the embryonic tectum. Recombinant RGM at low nanomolar concentration induces collapse of temporal but not of nasal growth cones and guides temporal retinal axons in vitro, demonstrating its repulsive and axon-specific guiding activity.

Suggested Citation

  • Philippe P. Monnier & Ana Sierra & Paolo Macchi & Lutz Deitinghoff & Jens S. Andersen & Matthias Mann & Manuela Flad & Martin R. Hornberger & Bernd Stahl & Friedrich Bonhoeffer & Bernhard K. Mueller, 2002. "RGM is a repulsive guidance molecule for retinal axons," Nature, Nature, vol. 419(6905), pages 392-395, September.
    • Handle: RePEc:nat:nature:v:419:y:2002:i:6905:d:10.1038_nature01041
    DOI: 10.1038/nature01041
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    Cited by:

    1. Qifang Wu & Chia Chi Sun & Herbert Y Lin & Jodie L Babitt, 2012. "Repulsive Guidance Molecule (RGM) Family Proteins Exhibit Differential Binding Kinetics for Bone Morphogenetic Proteins (BMPs)," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-8, September.
    2. Xue Fan Wang & Robin Vigouroux & Michal Syonov & Yuriy Baglaenko & Angeliki M. Nikolakopoulou & Dene Ringuette & Horea Rus & Peter V. DiStefano & Suzie Dufour & Alireza P. Shabanzadeh & Seunggi Lee & , 2024. "The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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