IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v418y2002i6899d10.1038_nature00957.html
   My bibliography  Save this article

A physical map of the mouse genome

Author

Listed:
  • Simon G. Gregory

    (The Wellcome Trust Sanger Institute)

  • Mandeep Sekhon

    (Genome Sequencing Center, Washington University School of Medicine)

  • Jacqueline Schein

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Shaying Zhao

    (The Institute for Genomic Research)

  • Kazutoyo Osoegawa

    (Children's Hospital Oakland Research Institute)

  • Carol E. Scott

    (The Wellcome Trust Sanger Institute)

  • Richard S. Evans

    (The Wellcome Trust Sanger Institute)

  • Paul W. Burridge

    (The Wellcome Trust Sanger Institute)

  • Tony V. Cox

    (The Wellcome Trust Sanger Institute)

  • Christopher A. Fox

    (The Wellcome Trust Sanger Institute)

  • Richard D. Hutton

    (The Wellcome Trust Sanger Institute)

  • Ian R. Mullenger

    (The Wellcome Trust Sanger Institute)

  • Kimbly J. Phillips

    (The Wellcome Trust Sanger Institute)

  • James Smith

    (The Wellcome Trust Sanger Institute)

  • Jim Stalker

    (The Wellcome Trust Sanger Institute)

  • Glen J. Threadgold

    (The Wellcome Trust Sanger Institute)

  • Ewan Birney

    (EMBL—European Bioinformatics Institute)

  • Kristine Wylie

    (Genome Sequencing Center, Washington University School of Medicine)

  • Asif Chinwalla

    (Genome Sequencing Center, Washington University School of Medicine)

  • John Wallis

    (Genome Sequencing Center, Washington University School of Medicine)

  • LaDeana Hillier

    (Genome Sequencing Center, Washington University School of Medicine)

  • Jason Carter

    (Genome Sequencing Center, Washington University School of Medicine)

  • Tony Gaige

    (Genome Sequencing Center, Washington University School of Medicine)

  • Sara Jaeger

    (Genome Sequencing Center, Washington University School of Medicine)

  • Colin Kremitzki

    (Genome Sequencing Center, Washington University School of Medicine)

  • Dan Layman

    (Genome Sequencing Center, Washington University School of Medicine)

  • Jason Maas

    (Genome Sequencing Center, Washington University School of Medicine)

  • Rebecca McGrane

    (Genome Sequencing Center, Washington University School of Medicine)

  • Kelly Mead

    (Genome Sequencing Center, Washington University School of Medicine)

  • Rebecca Walker

    (Genome Sequencing Center, Washington University School of Medicine)

  • Steven Jones

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Michael Smith

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Jennifer Asano

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Ian Bosdet

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Susanna Chan

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Suganthi Chittaranjan

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Readman Chiu

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Chris Fjell

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Dan Fuhrmann

    (Washington University)

  • Noreen Girn

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Catharine Gray

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Ran Guin

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Letticia Hsiao

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Martin Krzywinski

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Reta Kutsche

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Soo Sen Lee

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Carrie Mathewson

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Candice McLeavy

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Steve Messervier

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Steven Ness

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Pawan Pandoh

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Anna-Liisa Prabhu

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Parvaneh Saeedi

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Duane Smailus

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Lorraine Spence

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Jeff Stott

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Sheryl Taylor

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Wesley Terpstra

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Miranda Tsai

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Jill Vardy

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Natasja Wye

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • George Yang

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • Sofiya Shatsman

    (The Institute for Genomic Research)

  • Bola Ayodeji

    (The Institute for Genomic Research)

  • Keita Geer

    (The Institute for Genomic Research)

  • Getahun Tsegaye

    (The Institute for Genomic Research)

  • Alla Shvartsbeyn

    (The Institute for Genomic Research)

  • Elizabeth Gebregeorgis

    (The Institute for Genomic Research)

  • Margaret Krol

    (The Institute for Genomic Research)

  • Daniel Russell

    (The Institute for Genomic Research)

  • Larry Overton

    (The Institute for Genomic Research)

  • Joel A. Malek

    (The Institute for Genomic Research)

  • Mike Holmes

    (The Institute for Genomic Research)

  • Michael Heaney

    (The Institute for Genomic Research)

  • Jyoti Shetty

    (The Institute for Genomic Research)

  • Tamara Feldblyum

    (The Institute for Genomic Research)

  • William C. Nierman

    (The Institute for Genomic Research)

  • Joseph J. Catanese

    (Children's Hospital Oakland Research Institute)

  • Tim Hubbard

    (The Wellcome Trust Sanger Institute)

  • Robert H. Waterston

    (Genome Sequencing Center, Washington University School of Medicine)

  • Jane Rogers

    (The Wellcome Trust Sanger Institute)

  • Pieter J. de Jong

    (Children's Hospital Oakland Research Institute)

  • Claire M. Fraser

    (The Institute for Genomic Research)

  • Marco Marra

    (Genome Sciences Centre, British Columbia Cancer Agency)

  • John D. McPherson

    (Genome Sequencing Center, Washington University School of Medicine)

  • David R. Bentley

    (The Wellcome Trust Sanger Institute)

Abstract

A physical map of a genome is an essential guide for navigation, allowing the location of any gene or other landmark in the chromosomal DNA. We have constructed a physical map of the mouse genome that contains 296 contigs of overlapping bacterial clones and 16,992 unique markers. The mouse contigs were aligned to the human genome sequence on the basis of 51,486 homology matches, thus enabling use of the conserved synteny (correspondence between chromosome blocks) of the two genomes to accelerate construction of the mouse map. The map provides a framework for assembly of whole-genome shotgun sequence data, and a tile path of clones for generation of the reference sequence. Definition of the human–mouse alignment at this level of resolution enables identification of a mouse clone that corresponds to almost any position in the human genome. The human sequence may be used to facilitate construction of other mammalian genome maps using the same strategy.

Suggested Citation

  • Simon G. Gregory & Mandeep Sekhon & Jacqueline Schein & Shaying Zhao & Kazutoyo Osoegawa & Carol E. Scott & Richard S. Evans & Paul W. Burridge & Tony V. Cox & Christopher A. Fox & Richard D. Hutton &, 2002. "A physical map of the mouse genome," Nature, Nature, vol. 418(6899), pages 743-750, August.
    • Handle: RePEc:nat:nature:v:418:y:2002:i:6899:d:10.1038_nature00957
    DOI: 10.1038/nature00957
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature00957
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature00957?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:418:y:2002:i:6899:d:10.1038_nature00957. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.