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Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis

Author

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  • Petra Pandur

    (Universität Göttingen
    Abt Biochemie, Universität Ulm)

  • Matthias Läsche

    (Universität Göttingen)

  • Leonard M. Eisenberg

    (Medical University of South Carolina)

  • Michael Kühl

    (Universität Göttingen
    Abt Biochemie, Universität Ulm)

Abstract

Formation of the vertebrate heart requires a complex interplay of several temporally regulated signalling cascades1. In Xenopus laevis, cardiac specification occurs during gastrulation and requires signals from the dorsal lip and underlying endoderm2. Among known Xenopus Wnt genes, only Wnt-11 shows a spatiotemporal pattern of expression that correlates with cardiac specification, which indicates that Wnt-11 may be involved in heart development3,4. Here we show, through loss- and gain-of-function experiments, that XWnt-11 is required for heart formation in Xenopus embryos and is sufficient to induce a contractile phenotype in embryonic explants. Treating the mouse embryonic carcinoma stem cell line P19 with murine Wnt-11 conditioned medium triggers cardiogenesis, which indicates that the function of Wnt-11 in heart development has been conserved in higher vertebrates. XWnt-11 mediates this effect by non-canonical Wnt signalling, which is independent of β-catenin and involves protein kinase C and Jun amino-terminal kinase. Our results indicate that the cardiac developmental program requires non-canonical Wnt signal transduction.

Suggested Citation

  • Petra Pandur & Matthias Läsche & Leonard M. Eisenberg & Michael Kühl, 2002. "Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis," Nature, Nature, vol. 418(6898), pages 636-641, August.
    • Handle: RePEc:nat:nature:v:418:y:2002:i:6898:d:10.1038_nature00921
    DOI: 10.1038/nature00921
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    Cited by:

    1. Hua He & Chong Ma & Wei Wei & Haonan Wang & Yutian Lai & Ming Liu & Shenfei Sun & Qing Ma & Jiashuang Lai & Hanxiang Liu & Hanmin Liu & Fei Sun & Xinhua Lin, 2025. "Heparan sulfate regulates myofibroblast heterogeneity and function to mediate niche homeostasis during alveolar morphogenesis," Nature Communications, Nature, vol. 16(1), pages 1-17, December.
    2. Weiliang Jiang & Bingjie Guan & Hongcheng Sun & Yushuai Mi & Sanjun Cai & Rong Wan & Xinxiang Li & Peng Lian & Dawei Li & Senlin Zhao, 2025. "WNT11 Promotes immune evasion and resistance to Anti-PD-1 therapy in liver metastasis," Nature Communications, Nature, vol. 16(1), pages 1-18, December.

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