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Functions of FGF signalling from the apical ectodermal ridge in limb development

Author

Listed:
  • Xin Sun

    (University of Wisconsin)

  • Francesca V. Mariani
  • Gail R. Martin

    (University of California at San Francisco)

Abstract

To determine the role of fibroblast growth factor (FGF) signalling from the apical ectodermal ridge (AER), we inactivated Fgf4 and Fgf8 in AER cells or their precursors at different stages of mouse limb development. We show that FGF4 and FGF8 regulate cell number in the nascent limb bud and are required for survival of cells located far from the AER. On the basis of the skeletal phenotypes observed, we conclude that these functions are essential to ensure that sufficient progenitor cells are available to form the normal complement of skeletal elements, and perhaps other limb tissues. In the complete absence of both FGF4 and FGF8 activities, limb development fails. We present a model to explain how the mutant phenotypes arise from FGF-mediated effects on limb bud size and cell survival.

Suggested Citation

  • Xin Sun & Francesca V. Mariani & Gail R. Martin, 2002. "Functions of FGF signalling from the apical ectodermal ridge in limb development," Nature, Nature, vol. 418(6897), pages 501-508, August.
    • Handle: RePEc:nat:nature:v:418:y:2002:i:6897:d:10.1038_nature00902
    DOI: 10.1038/nature00902
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    Cited by:

    1. Sofia Sedas Perez & Caitlin McQueen & Holly Stainton & Joseph Pickering & Kavitha Chinnaiya & Patricia Saiz-Lopez & Marysia Placzek & Maria A. Ros & Matthew Towers, 2023. "Fgf signalling triggers an intrinsic mesodermal timer that determines the duration of limb patterning," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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