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The chemical repertoire of natural ribozymes

Author

Listed:
  • Jennifer A. Doudna

    (University of California)

  • Thomas R. Cech

    (Howard Hughes Medical Institute)

Abstract

Although RNA is generally thought to be a passive genetic blueprint, some RNA molecules, called ribozymes, have intrinsic enzyme-like activity — they can catalyse chemical reactions in the complete absence of protein cofactors. In addition to the well-known small ribozymes that cleave phosphodiester bonds, we now know that RNA catalysts probably effect a number of key cellular reactions. This versatility has lent credence to the idea that RNA molecules may have been central to the early stages of life on Earth.

Suggested Citation

  • Jennifer A. Doudna & Thomas R. Cech, 2002. "The chemical repertoire of natural ribozymes," Nature, Nature, vol. 418(6894), pages 222-228, July.
    • Handle: RePEc:nat:nature:v:418:y:2002:i:6894:d:10.1038_418222a
    DOI: 10.1038/418222a
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    Cited by:

    1. Jaroslaw Synak & Agnieszka Rybarczyk & Jacek Blazewicz, 2020. "Multi-agent approach to sequence structure simulation in the RNA World hypothesis," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-23, August.
    2. Bernat Bassols & Ernest Fontich & Daniel Oro & David Alonso & Josep Sardanyés, 2021. "Modelling Functional Shifts in Two-Species Hypercycles," Mathematics, MDPI, vol. 9(15), pages 1-22, July.

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