IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v418y2002i6893d10.1038_nature00900.html
   My bibliography  Save this article

Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease

Author

Listed:
  • Jong-Hoon Kim

    (National Institute of Neurological Disorders and Stroke, National Institute of Health)

  • Jonathan M. Auerbach

    (NeuralStem, Inc.
    College of Medicine, Hanyang University
    University of California
    Harvard Medical School, McLean Hospital)

  • José A. Rodríguez-Gómez

    (National Institute of Neurological Disorders and Stroke, National Institute of Health)

  • Iván Velasco

    (National Institute of Neurological Disorders and Stroke, National Institute of Health)

  • Denise Gavin

    (National Institute of Neurological Disorders and Stroke, National Institute of Health)

  • Nadya Lumelsky

    (National Institute of Neurological Disorders and Stroke, National Institute of Health)

  • Sang-Hun Lee

    (National Institute of Neurological Disorders and Stroke, National Institute of Health
    NeuralStem, Inc.
    College of Medicine, Hanyang University
    University of California)

  • John Nguyen

    (National Institute of Neurological Disorders and Stroke, National Institute of Health
    NeuralStem, Inc.
    College of Medicine, Hanyang University
    University of California)

  • Rosario Sánchez-Pernaute

    (National Institute of Neurological Disorders and Stroke, National Institute of Health
    NeuralStem, Inc.
    College of Medicine, Hanyang University
    University of California)

  • Krys Bankiewicz

    (National Institute of Neurological Disorders and Stroke, National Institute of Health
    NeuralStem, Inc.
    College of Medicine, Hanyang University
    University of California)

  • Ron McKay

    (National Institute of Neurological Disorders and Stroke, National Institute of Health)

Abstract

Parkinson's disease is a widespread condition caused by the loss of midbrain neurons that synthesize the neurotransmitter dopamine. Cells derived from the fetal midbrain can modify the course of the disease, but they are an inadequate source of dopamine-synthesizing neurons because their ability to generate these neurons is unstable. In contrast, embryonic stem (ES) cells proliferate extensively and can generate dopamine neurons. If ES cells are to become the basis for cell therapies, we must develop methods of enriching for the cell of interest and demonstrate that these cells show functions that will assist in treating the disease. Here we show that a highly enriched population of midbrain neural stem cells can be derived from mouse ES cells. The dopamine neurons generated by these stem cells show electrophysiological and behavioural properties expected of neurons from the midbrain. Our results encourage the use of ES cells in cell-replacement therapy for Parkinson's disease.

Suggested Citation

  • Jong-Hoon Kim & Jonathan M. Auerbach & José A. Rodríguez-Gómez & Iván Velasco & Denise Gavin & Nadya Lumelsky & Sang-Hun Lee & John Nguyen & Rosario Sánchez-Pernaute & Krys Bankiewicz & Ron McKay, 2002. "Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease," Nature, Nature, vol. 418(6893), pages 50-56, July.
    • Handle: RePEc:nat:nature:v:418:y:2002:i:6893:d:10.1038_nature00900
    DOI: 10.1038/nature00900
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature00900
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature00900?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:418:y:2002:i:6893:d:10.1038_nature00900. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.