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Sequence and analysis of chromosome 2 of Dictyostelium discoideum

Author

Listed:
  • Gernot Glöckner

    (IMB Jena, Department of Genome Analysis)

  • Ludwig Eichinger

    (Center for Biochemistry, Medical Faculty, University of Cologne)

  • Karol Szafranski

    (IMB Jena, Department of Genome Analysis)

  • Justin A. Pachebat

    (Medical Research Council Laboratory of Molecular Biology, MRC Centre)

  • Alan T. Bankier

    (Medical Research Council Laboratory of Molecular Biology, MRC Centre)

  • Paul H. Dear

    (Medical Research Council Laboratory of Molecular Biology, MRC Centre)

  • Rüdiger Lehmann

    (IMB Jena, Department of Genome Analysis)

  • Cornelia Baumgart

    (IMB Jena, Department of Genome Analysis)

  • Genís Parra

    (Grup de Recerca en Informatica Biomedica, Institut Municipal d'Inveastigació Mèdica, Universitat Pompeu Fabra, Centre de Regulació Genòmica)

  • Josep F. Abril

    (Grup de Recerca en Informatica Biomedica, Institut Municipal d'Inveastigació Mèdica, Universitat Pompeu Fabra, Centre de Regulació Genòmica)

  • Roderic Guigó

    (Grup de Recerca en Informatica Biomedica, Institut Municipal d'Inveastigació Mèdica, Universitat Pompeu Fabra, Centre de Regulació Genòmica)

  • Kai Kumpf

    (IMB Jena, Department of Genome Analysis)

  • Budi Tunggal

    (Center for Biochemistry, Medical Faculty, University of Cologne)

  • Edward Cox

    (Princeton University)

  • Michael A. Quail

    (The Sanger Institute, Wellcome Trust Genome Campus)

  • Matthias Platzer

    (IMB Jena, Department of Genome Analysis)

  • André Rosenthal

    (Friedrich Schiller Universität)

  • Angelika A. Noegel

    (Center for Biochemistry, Medical Faculty, University of Cologne)

  • Bart G. Barrell

    (The Sanger Institute, Wellcome Trust Genome Campus)

  • Marie-Adèle Rajandream

    (The Sanger Institute, Wellcome Trust Genome Campus)

  • Jeffrey G. Williams

    (University of Dundee, MSI/WTB Complex)

  • Robert R. Kay

    (MRC Laboratory, of Molecular Biology)

  • Adam Kuspa

    (Baylor College of Medicine)

  • Richard Gibbs

    (Baylor College of Medicine)

  • Richard Sucgang

    (Baylor College of Medicine)

  • Donna Muzny

    (Baylor College of Medicine)

  • Brian Desany

    (Baylor College of Medicine)

  • Kathy Zeng

    (Children's Hospital Oakland – BACPAC Resources)

  • Baoli Zhu

    (Children's Hospital Oakland – BACPAC Resources)

  • Pieter de Jong

    (Children's Hospital Oakland – BACPAC Resources)

  • Theodor Dingermann

    (Institut für Pharmazeutische Biologie, Universität Frankfurt (Biozentrum))

  • Günther Gerisch

    (Max-Planck-Institut für Biochemie)

  • Peter Philippsen

    (Molecular Microbiology, Biozentrum der Universität)

  • Michael Schleicher

    (A.-Butenandt-Institut/Zellbiologie, Ludwig-Maximilians-Universität)

  • Stephan C. Schuster

    (Max-Planck-Institut für Entwicklungsbiologie)

  • Thomas Winckler

    (Institut für Pharmazeutische Biologie, Universität Frankfurt (Biozentrum))

Abstract

The genome of the lower eukaryote Dictyostelium discoideum comprises six chromosomes. Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of the genome. Despite an A + T content of nearly 80%, the chromosome codes for 2,799 predicted protein coding genes and 73 transfer RNA genes. This gene density, about 1 gene per 2.6 kilobases (kb), is surpassed only by Saccharomyces cerevisiae (one per 2 kb) and is similar to that of Schizosaccharomyces pombe (one per 2.5 kb)1,2. If we assume that the other chromosomes have a similar gene density, we can expect around 11,000 genes in the D. discoideum genome. A significant number of the genes show higher similarities to genes of vertebrates than to those of other fully sequenced eukaryotes1,2,3,4,5,6. This analysis strengthens the view that the evolutionary position of D. discoideum is located before the branching of metazoa and fungi but after the divergence of the plant kingdom7, placing it close to the base of metazoan evolution.

Suggested Citation

  • Gernot Glöckner & Ludwig Eichinger & Karol Szafranski & Justin A. Pachebat & Alan T. Bankier & Paul H. Dear & Rüdiger Lehmann & Cornelia Baumgart & Genís Parra & Josep F. Abril & Roderic Guigó & Kai K, 2002. "Sequence and analysis of chromosome 2 of Dictyostelium discoideum," Nature, Nature, vol. 418(6893), pages 79-85, July.
    • Handle: RePEc:nat:nature:v:418:y:2002:i:6893:d:10.1038_nature00847
    DOI: 10.1038/nature00847
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