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RNA interference in adult mice

Author

Listed:
  • Anton P. McCaffrey

    (Stanford University School of Medicine)

  • Leonard Meuse

    (Stanford University School of Medicine)

  • Thu-Thao T. Pham

    (Stanford University School of Medicine)

  • Douglas S. Conklin

    (Cold Spring Harbor Laboratory)

  • Gregory J. Hannon

    (Cold Spring Harbor Laboratory)

  • Mark A. Kay

    (Stanford University School of Medicine)

Abstract

RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from DNA templates. We also show the therapeutic potential of this technique by demonstrating effective targeting of a sequence from hepatitis C virus by RNA interference in vivo.

Suggested Citation

  • Anton P. McCaffrey & Leonard Meuse & Thu-Thao T. Pham & Douglas S. Conklin & Gregory J. Hannon & Mark A. Kay, 2002. "RNA interference in adult mice," Nature, Nature, vol. 418(6893), pages 38-39, July.
    • Handle: RePEc:nat:nature:v:418:y:2002:i:6893:d:10.1038_418038a
    DOI: 10.1038/418038a
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