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Early-pregnancy origins of low birth weight

Author

Listed:
  • Gordon C. S. Smith

    (University of Cambridge, The Rosie Hospital)

  • Emily J. Stenhouse

    (The Queen Mother's Hospital)

  • Jennifer A. Crossley

    (Institute of Medical Genetics, Yorkhill NHS Trust)

  • David A. Aitken

    (Institute of Medical Genetics, Yorkhill NHS Trust)

  • Alan D. Cameron

    (The Queen Mother's Hospital)

  • J. Michael Connor

    (Institute of Medical Genetics, Yorkhill NHS Trust)

Abstract

Low birth weight is a significant cause of morbidity and mortality among newborns, and may result from impaired placental function during the first trimester of pregnancy1. Here we show that the risk of delivering a low-birth-weight baby at term after an uncomplicated pregnancy varies with maternal circulating concentrations of a placental protein, pregnancy-associated plasma protein-A (PAPP-A) in the first 10 weeks after conception. Poor fetal growth may therefore already have been determined by the time obstetric monitoring begins after completion of the first trimester.

Suggested Citation

  • Gordon C. S. Smith & Emily J. Stenhouse & Jennifer A. Crossley & David A. Aitken & Alan D. Cameron & J. Michael Connor, 2002. "Early-pregnancy origins of low birth weight," Nature, Nature, vol. 417(6892), pages 916-916, June.
    • Handle: RePEc:nat:nature:v:417:y:2002:i:6892:d:10.1038_417916a
    DOI: 10.1038/417916a
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    Cited by:

    1. Jonas Helgertz & Tommy Bengtsson, 2019. "The Long-Lasting Influenza: The Impact of Fetal Stress During the 1918 Influenza Pandemic on Socioeconomic Attainment and Health in Sweden, 1968–2012," Demography, Springer;Population Association of America (PAA), vol. 56(4), pages 1389-1425, August.

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