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Regulation of AMPA receptor lateral movements

Author

Listed:
  • Aren J. Borgdorff

    (CNRS UMR 5091)

  • Daniel Choquet

    (CNRS UMR 5091)

Abstract

An essential feature in the modulation of the efficacy of synaptic transmission is rapid changes in the number of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors at post-synaptic sites on neurons1,2,3,4. Regulation of receptor endo- and exocytosis has been shown to be involved in this process5,6,7,8,9,10,11,12,13,14. Whether regulated lateral diffusion of receptors in the plasma membrane also participates in receptor exchange to and from post-synaptic sites remains unknown. We analysed the lateral mobility of native AMPA receptors containing the glutamate receptor subunit GluR2 in rat cultured hippocampal neurons, using single-particle tracking and video microscopy. Here we show that AMPA receptors alternate within seconds between rapid diffusive and stationary behaviour. During maturation of neurons, stationary periods increase in frequency and length, often in spatial correlation with synaptic sites. Raising intracellular calcium, a central element in synaptic plasticity, triggers rapid receptor immobilization and local accumulation on the neuronal surface. We suggest that calcium influx prevents AMPA receptors from diffusing, and that lateral receptor diffusion to and from synaptic sites acts in the rapid and controlled regulation of receptor numbers at synapses.

Suggested Citation

  • Aren J. Borgdorff & Daniel Choquet, 2002. "Regulation of AMPA receptor lateral movements," Nature, Nature, vol. 417(6889), pages 649-653, June.
    • Handle: RePEc:nat:nature:v:417:y:2002:i:6889:d:10.1038_nature00780
    DOI: 10.1038/nature00780
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    Cited by:

    1. Nathan Bénac & G. Ezequiel Saraceno & Corey Butler & Nahoko Kuga & Yuya Nishimura & Taiki Yokoi & Ping Su & Takuya Sasaki & Mar Petit-Pedrol & Rémi Galland & Vincent Studer & Fang Liu & Yuji Ikegaya &, 2024. "Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Rahul Gupta, 2018. "Self-crowding of AMPA receptors in the excitatory postsynaptic density can effectuate anomalous receptor sub-diffusion," PLOS Computational Biology, Public Library of Science, vol. 14(2), pages 1-34, February.

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