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Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

Author

Listed:
  • S. D. Bentley

    (Wellcome Trust Genome Campus)

  • K. F. Chater

    (John Innes Centre, Norwich Research Park)

  • A.-M. Cerdeño-Tárraga

    (Wellcome Trust Genome Campus)

  • G. L. Challis

    (John Innes Centre, Norwich Research Park
    University of Warwick)

  • N. R. Thomson

    (Wellcome Trust Genome Campus)

  • K. D. James

    (Wellcome Trust Genome Campus)

  • D. E. Harris

    (Wellcome Trust Genome Campus)

  • M. A. Quail

    (Wellcome Trust Genome Campus)

  • H. Kieser

    (John Innes Centre, Norwich Research Park)

  • D. Harper

    (Wellcome Trust Genome Campus)

  • A. Bateman

    (Wellcome Trust Genome Campus)

  • S. Brown

    (Wellcome Trust Genome Campus)

  • G. Chandra

    (John Innes Centre, Norwich Research Park)

  • C. W. Chen

    (National Yang-Ming University)

  • M. Collins

    (Wellcome Trust Genome Campus)

  • A. Cronin

    (Wellcome Trust Genome Campus)

  • A. Fraser

    (Wellcome Trust Genome Campus)

  • A. Goble

    (Wellcome Trust Genome Campus)

  • J. Hidalgo

    (Wellcome Trust Genome Campus)

  • T. Hornsby

    (Wellcome Trust Genome Campus)

  • S. Howarth

    (Wellcome Trust Genome Campus)

  • C.-H. Huang

    (National Yang-Ming University)

  • T. Kieser

    (John Innes Centre, Norwich Research Park)

  • L. Larke

    (Wellcome Trust Genome Campus)

  • L. Murphy

    (Wellcome Trust Genome Campus)

  • K. Oliver

    (Wellcome Trust Genome Campus)

  • S. O'Neil

    (Wellcome Trust Genome Campus)

  • E. Rabbinowitsch

    (Wellcome Trust Genome Campus)

  • M.-A. Rajandream

    (Wellcome Trust Genome Campus)

  • K. Rutherford

    (Wellcome Trust Genome Campus)

  • S. Rutter

    (Wellcome Trust Genome Campus)

  • K. Seeger

    (Wellcome Trust Genome Campus)

  • D. Saunders

    (Wellcome Trust Genome Campus)

  • S. Sharp

    (Wellcome Trust Genome Campus)

  • R. Squares

    (Wellcome Trust Genome Campus)

  • S. Squares

    (Wellcome Trust Genome Campus)

  • K. Taylor

    (Wellcome Trust Genome Campus)

  • T. Warren

    (Wellcome Trust Genome Campus)

  • A. Wietzorrek

    (John Innes Centre, Norwich Research Park)

  • J. Woodward

    (Wellcome Trust Genome Campus)

  • B. G. Barrell

    (Wellcome Trust Genome Campus)

  • J. Parkhill

    (Wellcome Trust Genome Campus)

  • D. A. Hopwood

    (John Innes Centre, Norwich Research Park)

Abstract

Streptomyces coelicolor is a representative of the group of soil-dwelling, filamentous bacteria responsible for producing most natural antibiotics used in human and veterinary medicine. Here we report the 8,667,507 base pair linear chromosome of this organism, containing the largest number of genes so far discovered in a bacterium. The 7,825 predicted genes include more than 20 clusters coding for known or predicted secondary metabolites. The genome contains an unprecedented proportion of regulatory genes, predominantly those likely to be involved in responses to external stimuli and stresses, and many duplicated gene sets that may represent ‘tissue-specific’ isoforms operating in different phases of colonial development, a unique situation for a bacterium. An ancient synteny was revealed between the central ‘core’ of the chromosome and the whole chromosome of pathogens Mycobacterium tuberculosis and Corynebacterium diphtheriae. The genome sequence will greatly increase our understanding of microbial life in the soil as well as aiding the generation of new drug candidates by genetic engineering.

Suggested Citation

  • S. D. Bentley & K. F. Chater & A.-M. Cerdeño-Tárraga & G. L. Challis & N. R. Thomson & K. D. James & D. E. Harris & M. A. Quail & H. Kieser & D. Harper & A. Bateman & S. Brown & G. Chandra & C. W. Che, 2002. "Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)," Nature, Nature, vol. 417(6885), pages 141-147, May.
  • Handle: RePEc:nat:nature:v:417:y:2002:i:6885:d:10.1038_417141a
    DOI: 10.1038/417141a
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    Citations

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    Cited by:

    1. Hiroshi Otani & Nigel J. Mouncey, 2022. "RIViT-seq enables systematic identification of regulons of transcriptional machineries," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Alexander Bogdanov & Mariam N. Salib & Alexander B. Chase & Heinz Hammerlindl & Mitchell N. Muskat & Stephanie Luedtke & Elany Barbosa Silva & Anthony J. O’Donoghue & Lani F. Wu & Steven J. Altschuler, 2024. "Small molecule in situ resin capture provides a compound first approach to natural product discovery," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Ben O. Oyserman & Stalin Sarango Flores & Thom Griffioen & Xinya Pan & Elmar Wijk & Lotte Pronk & Wouter Lokhorst & Azkia Nurfikari & Joseph N. Paulson & Mercedeh Movassagh & Nejc Stopnisek & Anne Kup, 2022. "Disentangling the genetic basis of rhizosphere microbiome assembly in tomato," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Zheren Zhang & Shraddha Shitut & Bart Claushuis & Dennis Claessen & Daniel E. Rozen, 2022. "Mutational meltdown of putative microbial altruists in Streptomyces coelicolor colonies," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    5. Hegne Pupart & Piia Jõul & Melissa Ingela Bramanis & Tiit Lukk, 2023. "Characterization of the Ensemble of Lignin-Remodeling DyP-Type Peroxidases from Streptomyces coelicolor A3(2)," Energies, MDPI, vol. 16(3), pages 1-15, February.

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