IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v417y2002i6885d10.1038_417141a.html
   My bibliography  Save this article

Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

Author

Listed:
  • S. D. Bentley

    (Wellcome Trust Genome Campus)

  • K. F. Chater

    (John Innes Centre, Norwich Research Park)

  • A.-M. Cerdeño-Tárraga

    (Wellcome Trust Genome Campus)

  • G. L. Challis

    (John Innes Centre, Norwich Research Park
    University of Warwick)

  • N. R. Thomson

    (Wellcome Trust Genome Campus)

  • K. D. James

    (Wellcome Trust Genome Campus)

  • D. E. Harris

    (Wellcome Trust Genome Campus)

  • M. A. Quail

    (Wellcome Trust Genome Campus)

  • H. Kieser

    (John Innes Centre, Norwich Research Park)

  • D. Harper

    (Wellcome Trust Genome Campus)

  • A. Bateman

    (Wellcome Trust Genome Campus)

  • S. Brown

    (Wellcome Trust Genome Campus)

  • G. Chandra

    (John Innes Centre, Norwich Research Park)

  • C. W. Chen

    (National Yang-Ming University)

  • M. Collins

    (Wellcome Trust Genome Campus)

  • A. Cronin

    (Wellcome Trust Genome Campus)

  • A. Fraser

    (Wellcome Trust Genome Campus)

  • A. Goble

    (Wellcome Trust Genome Campus)

  • J. Hidalgo

    (Wellcome Trust Genome Campus)

  • T. Hornsby

    (Wellcome Trust Genome Campus)

  • S. Howarth

    (Wellcome Trust Genome Campus)

  • C.-H. Huang

    (National Yang-Ming University)

  • T. Kieser

    (John Innes Centre, Norwich Research Park)

  • L. Larke

    (Wellcome Trust Genome Campus)

  • L. Murphy

    (Wellcome Trust Genome Campus)

  • K. Oliver

    (Wellcome Trust Genome Campus)

  • S. O'Neil

    (Wellcome Trust Genome Campus)

  • E. Rabbinowitsch

    (Wellcome Trust Genome Campus)

  • M.-A. Rajandream

    (Wellcome Trust Genome Campus)

  • K. Rutherford

    (Wellcome Trust Genome Campus)

  • S. Rutter

    (Wellcome Trust Genome Campus)

  • K. Seeger

    (Wellcome Trust Genome Campus)

  • D. Saunders

    (Wellcome Trust Genome Campus)

  • S. Sharp

    (Wellcome Trust Genome Campus)

  • R. Squares

    (Wellcome Trust Genome Campus)

  • S. Squares

    (Wellcome Trust Genome Campus)

  • K. Taylor

    (Wellcome Trust Genome Campus)

  • T. Warren

    (Wellcome Trust Genome Campus)

  • A. Wietzorrek

    (John Innes Centre, Norwich Research Park)

  • J. Woodward

    (Wellcome Trust Genome Campus)

  • B. G. Barrell

    (Wellcome Trust Genome Campus)

  • J. Parkhill

    (Wellcome Trust Genome Campus)

  • D. A. Hopwood

    (John Innes Centre, Norwich Research Park)

Abstract

Streptomyces coelicolor is a representative of the group of soil-dwelling, filamentous bacteria responsible for producing most natural antibiotics used in human and veterinary medicine. Here we report the 8,667,507 base pair linear chromosome of this organism, containing the largest number of genes so far discovered in a bacterium. The 7,825 predicted genes include more than 20 clusters coding for known or predicted secondary metabolites. The genome contains an unprecedented proportion of regulatory genes, predominantly those likely to be involved in responses to external stimuli and stresses, and many duplicated gene sets that may represent ‘tissue-specific’ isoforms operating in different phases of colonial development, a unique situation for a bacterium. An ancient synteny was revealed between the central ‘core’ of the chromosome and the whole chromosome of pathogens Mycobacterium tuberculosis and Corynebacterium diphtheriae. The genome sequence will greatly increase our understanding of microbial life in the soil as well as aiding the generation of new drug candidates by genetic engineering.

Suggested Citation

  • S. D. Bentley & K. F. Chater & A.-M. Cerdeño-Tárraga & G. L. Challis & N. R. Thomson & K. D. James & D. E. Harris & M. A. Quail & H. Kieser & D. Harper & A. Bateman & S. Brown & G. Chandra & C. W. Che, 2002. "Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)," Nature, Nature, vol. 417(6885), pages 141-147, May.
  • Handle: RePEc:nat:nature:v:417:y:2002:i:6885:d:10.1038_417141a
    DOI: 10.1038/417141a
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/417141a
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/417141a?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Qiu Liu & Changjian Liu & Jicheng Yu & Jianfang Yan & Xiaohui Qi, 2012. "Analysis of the Ketosynthase Genes in Streptomyces and Its Implications for Preventing Reinvestigation of Polyketides with Bioactivities," Journal of Agricultural Science, Canadian Center of Science and Education, vol. 4(7), pages 262-262, May.
    2. Ben O. Oyserman & Stalin Sarango Flores & Thom Griffioen & Xinya Pan & Elmar Wijk & Lotte Pronk & Wouter Lokhorst & Azkia Nurfikari & Joseph N. Paulson & Mercedeh Movassagh & Nejc Stopnisek & Anne Kup, 2022. "Disentangling the genetic basis of rhizosphere microbiome assembly in tomato," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Zheren Zhang & Shraddha Shitut & Bart Claushuis & Dennis Claessen & Daniel E. Rozen, 2022. "Mutational meltdown of putative microbial altruists in Streptomyces coelicolor colonies," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    4. Hegne Pupart & Piia Jõul & Melissa Ingela Bramanis & Tiit Lukk, 2023. "Characterization of the Ensemble of Lignin-Remodeling DyP-Type Peroxidases from Streptomyces coelicolor A3(2)," Energies, MDPI, vol. 16(3), pages 1-15, February.
    5. Hiroshi Otani & Nigel J. Mouncey, 2022. "RIViT-seq enables systematic identification of regulons of transcriptional machineries," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    6. Alexander Bogdanov & Mariam N. Salib & Alexander B. Chase & Heinz Hammerlindl & Mitchell N. Muskat & Stephanie Luedtke & Elany Barbosa Silva & Anthony J. O’Donoghue & Lani F. Wu & Steven J. Altschuler, 2024. "Small molecule in situ resin capture provides a compound first approach to natural product discovery," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:417:y:2002:i:6885:d:10.1038_417141a. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.