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Cells compete for Decapentaplegic survival factor to prevent apoptosis in Drosophila wing development

Author

Listed:
  • Eduardo Moreno

    (Universität Zürich
    Centro de Biologia Molecular CSIC-UAM)

  • Konrad Basler

    (Universität Zürich)

  • Ginés Morata

    (Centro de Biologia Molecular CSIC-UAM)

Abstract

During the growth of Drosophila imaginal discs a process called ‘cell competition’1 eliminates slow-proliferating but otherwise viable cells. We report here that cell competition requires the function of the brinker (brk) gene, whose expression is normally repressed by Decapentaplegic (Dpp) signalling2,3,4 but is upregulated in slow-growing Minute/+ cells. Excess brk expression activates the c-Jun amino-terminal kinase pathway, which in turn triggers apoptosis in these cells. We propose that slow-proliferating cells upregulate Brk levels owing to a disadvantage in competing for, or in transducing, the Dpp survival signal. This sequence of events might represent a general mechanism by which weaker cells are eliminated from a growing population, and might serve as a method of controlling cell number and optimizing tissue fitness and hence organ function.

Suggested Citation

  • Eduardo Moreno & Konrad Basler & Ginés Morata, 2002. "Cells compete for Decapentaplegic survival factor to prevent apoptosis in Drosophila wing development," Nature, Nature, vol. 416(6882), pages 755-759, April.
  • Handle: RePEc:nat:nature:v:416:y:2002:i:6882:d:10.1038_416755a
    DOI: 10.1038/416755a
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    Cited by:

    1. Marianna Yusupova & Roi Ankawa & Yahav Yosefzon & David Meiri & Ido Bachelet & Yaron Fuchs, 2023. "Apoptotic dysregulation mediates stem cell competition and tissue regeneration," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Michael E. Baumgartner & Paul F. Langton & Remi Logeay & Alex Mastrogiannopoulos & Anna Nilsson-Takeuchi & Iwo Kucinski & Jules Lavalou & Eugenia Piddini, 2023. "The PECAn image and statistical analysis pipeline identifies Minute cell competition genes and features," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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