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Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

Author

Listed:
  • Naohiro Terada

    (University of Florida College of Medicine
    University of Florida College of Medicine)

  • Takashi Hamazaki

    (University of Florida College of Medicine)

  • Masahiro Oka

    (University of Florida College of Medicine)

  • Masanori Hoki

    (University of Florida College of Medicine)

  • Diana M. Mastalerz

    (University of Florida College of Medicine)

  • Yuka Nakano

    (University of Florida College of Medicine)

  • Edwin M. Meyer

    (University of Florida College of Medicine)

  • Laurence Morel

    (University of Florida College of Medicine)

  • Bryon E. Petersen

    (University of Florida College of Medicine
    University of Florida College of Medicine)

  • Edward W. Scott

    (University of Florida College of Medicine
    University of Florida College of Medicine)

Abstract

Recent studies have demonstrated that transplanted bone marrow cells can turn into unexpected lineages including myocytes, hepatocytes, neurons and many others1. A potential problem, however, is that reports discussing such ‘transdifferentiation’ in vivo tend to conclude donor origin of transdifferentiated cells on the basis of the existence of donor-specific genes such as Y-chromosome markers1. Here we demonstrate that mouse bone marrow cells can fuse spontaneously with embryonic stem cells in culture in vitro that contains interleukin-3. Moreover, spontaneously fused bone marrow cells can subsequently adopt the phenotype of the recipient cells, which, without detailed genetic analysis, might be interpreted as ‘dedifferentiation’ or transdifferentiation.

Suggested Citation

  • Naohiro Terada & Takashi Hamazaki & Masahiro Oka & Masanori Hoki & Diana M. Mastalerz & Yuka Nakano & Edwin M. Meyer & Laurence Morel & Bryon E. Petersen & Edward W. Scott, 2002. "Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion," Nature, Nature, vol. 416(6880), pages 542-545, April.
    • Handle: RePEc:nat:nature:v:416:y:2002:i:6880:d:10.1038_nature730
    DOI: 10.1038/nature730
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