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Rac function and regulation during Drosophila development

Author

Listed:
  • Satoko Hakeda-Suzuki

    (Research Institute of Molecular Pathology)

  • Julian Ng

    (Stanford University)

  • Julia Tzu

    (Stanford University)

  • Georg Dietzl

    (Research Institute of Molecular Pathology)

  • Yan Sun

    (Research Institute of Molecular Pathology)

  • Matthew Harms

    (Stanford University)

  • Tim Nardine

    (Stanford University)

  • Liqun Luo

    (Stanford University
    Stanford University)

  • Barry J. Dickson

    (Research Institute of Molecular Pathology)

Abstract

Rac GTPases regulate the actin cytoskeleton to control changes in cell shape1,2. To date, the analysis of Rac function during development has relied heavily on the use of dominant mutant isoforms. Here, we use loss-of-function mutations to show that the three Drosophila Rac genes, Rac1, Rac2 and Mtl, have overlapping functions in the control of epithelial morphogenesis, myoblast fusion, and axon growth and guidance. They are not required for the establishment of planar cell polarity, as had been suggested on the basis of studies using dominant mutant isoforms3,4. The guanine nucleotide exchange factor, Trio, is essential for Rac function in axon growth and guidance, but not for epithelial morphogenesis or myoblast fusion. Different Rac activators thus act in different developmental processes. The specific cellular response to Rac activation may be determined more by the upstream activator than the specific Rac protein involved.

Suggested Citation

  • Satoko Hakeda-Suzuki & Julian Ng & Julia Tzu & Georg Dietzl & Yan Sun & Matthew Harms & Tim Nardine & Liqun Luo & Barry J. Dickson, 2002. "Rac function and regulation during Drosophila development," Nature, Nature, vol. 416(6879), pages 438-442, March.
    • Handle: RePEc:nat:nature:v:416:y:2002:i:6879:d:10.1038_416438a
    DOI: 10.1038/416438a
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    Cited by:

    1. Viviane Tran & Sarah Nahlé & Amélie Robert & Inès Desanlis & Ryan Killoran & Sophie Ehresmann & Marie-Pier Thibault & David Barford & Kodi S. Ravichandran & Martin Sauvageau & Matthew J. Smith & Marie, 2022. "Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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