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Identification of a cold receptor reveals a general role for TRP channels in thermosensation

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  • David D. McKemy

    (University of California)

  • Werner M. Neuhausser

    (University of California)

  • David Julius

    (University of California)

Abstract

The cellular and molecular mechanisms that enable us to sense cold are not well understood. Insights into this process have come from the use of pharmacological agents, such as menthol, that elicit a cooling sensation. Here we have characterized and cloned a menthol receptor from trigeminal sensory neurons that is also activated by thermal stimuli in the cool to cold range. This cold- and menthol-sensitive receptor, CMR1, is a member of the TRP family of excitatory ion channels, and we propose that it functions as a transducer of cold stimuli in the somatosensory system. These findings, together with our previous identification of the heat-sensitive channels VR1 and VRL-1, demonstrate that TRP channels detect temperatures over a wide range and are the principal sensors of thermal stimuli in the mammalian peripheral nervous system.

Suggested Citation

  • David D. McKemy & Werner M. Neuhausser & David Julius, 2002. "Identification of a cold receptor reveals a general role for TRP channels in thermosensation," Nature, Nature, vol. 416(6876), pages 52-58, March.
    • Handle: RePEc:nat:nature:v:416:y:2002:i:6876:d:10.1038_nature719
    DOI: 10.1038/nature719
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    Cited by:

    1. Erick Olivares & Simón Salgado & Jean Paul Maidana & Gaspar Herrera & Matías Campos & Rodolfo Madrid & Patricio Orio, 2015. "TRPM8-Dependent Dynamic Response in a Mathematical Model of Cold Thermoreceptor," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-17, October.
    2. Chenxi Lin & Yuxin Shan & Zhongyi Wang & Hui Peng & Rong Li & Pingzhou Wang & Junyan He & Weiwei Shen & Zhengxing Wu & Min Guo, 2024. "Molecular and circuit mechanisms underlying avoidance of rapid cooling stimuli in C. elegans," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Cheng Zhao & Yuan Xie & Lizhen Xu & Fan Ye & Ximing Xu & Wei Yang & Fan Yang & Jiangtao Guo, 2022. "Structures of a mammalian TRPM8 in closed state," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. Hiroki Ota & Kimiaki Katanosaka & Shiori Murase & Makiko Kashio & Makoto Tominaga & Kazue Mizumura, 2013. "TRPV1 and TRPV4 Play Pivotal Roles in Delayed Onset Muscle Soreness," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-10, June.
    5. Ivo B. Regli & Giacomo Strapazzon & Marika Falla & Rosmarie Oberhammer & Hermann Brugger, 2021. "Long-Term Sequelae of Frostbite—A Scoping Review," IJERPH, MDPI, vol. 18(18), pages 1-16, September.
    6. Patricia Aroni & Ligia F. Fonseca & Marcia A. Ciol & Amanda S. Margatho & Cristina M. Galvão, 2020. "The use of mentholated popsicle to reduce thirst during preoperative fasting: A randomised controlled trial," Journal of Clinical Nursing, John Wiley & Sons, vol. 29(5-6), pages 840-851, March.
    7. Michael A Ha & Gregory J Smith & Joseph A Cichocki & Lu Fan & Yi-Shiuan Liu & Ana I Caceres & Sven Eric Jordt & John B Morris, 2015. "Menthol Attenuates Respiratory Irritation and Elevates Blood Cotinine in Cigarette Smoke Exposed Mice," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-16, February.

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