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Amplification by compartmentalization

Author

Listed:
  • Jian Chen

    (Skaggs Institute for Chemical Biology, Scripps Research Institute)

  • Steffi Körner

    (Skaggs Institute for Chemical Biology, Scripps Research Institute)

  • Stephen L. Craig

    (Duke University)

  • Dmitry M. Rudkevich

    (University of Texas at Arlington)

  • Julius Rebek

    (Skaggs Institute for Chemical Biology, Scripps Research Institute)

Abstract

Autocatalysis and chemical amplification are properties of living systems that can lead to increased responsiveness and to self-replication. Here we describe a synthetic system in which a unique form of reagent compartmentalization gives rise to nonlinear kinetics that are subject to the precise size- and shape-selectivity of the host. The reactivity is reminiscent of autocatalytic behaviour1, in which there is no direct contact between reagents and products, and our approach offers a general way to impose complex chemical behaviour onto synthetic systems.

Suggested Citation

  • Jian Chen & Steffi Körner & Stephen L. Craig & Dmitry M. Rudkevich & Julius Rebek, 2002. "Amplification by compartmentalization," Nature, Nature, vol. 415(6870), pages 385-386, January.
    • Handle: RePEc:nat:nature:v:415:y:2002:i:6870:d:10.1038_415385b
    DOI: 10.1038/415385b
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