IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v414y2001i6865d10.1038_414788a.html
   My bibliography  Save this article

Diabetes mellitus and genetically programmed defects in β-cell function

Author

Listed:
  • Graeme I. Bell

    (Medicine and Human Genetics, The University of Chicago)

  • Kenneth S. Polonsky

    (Washington University School of Medicine)

Abstract

The pathways that control insulin secretion and regulate pancreatic β-cell mass are crucial in the development of diabetes mellitus. Maturity-onset diabetes of the young comprises a number of single-gene disorders affecting pancreatic β-cell function, and the consequences of mutations in these genes are so serious that diabetes develops in childhood or adolescence. A genetic basis for the more common form of type 2 diabetes, which affects 10–20% of adults in many developed countries, is less clear cut. It is also characterized by abnormal β-cell function, but other tissues are involved as well. However, in both forms identification of causative and susceptibility genes are providing new insight into the control of insulin action and secretion, as well as suggesting new treatments for diabetes.

Suggested Citation

  • Graeme I. Bell & Kenneth S. Polonsky, 2001. "Diabetes mellitus and genetically programmed defects in β-cell function," Nature, Nature, vol. 414(6865), pages 788-791, December.
    • Handle: RePEc:nat:nature:v:414:y:2001:i:6865:d:10.1038_414788a
    DOI: 10.1038/414788a
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/414788a
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/414788a?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ling Qiu & Risu Na & Rong Xu & Siyang Wang & Hongguang Sheng & Wanling Wu & Yi Qu, 2014. "Quantitative Assessment of the Effect of KCNJ11 Gene Polymorphism on the Risk of Type 2 Diabetes," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-9, April.
    2. Radwan H Ahmed & Hasniza Zaman Huri & Zaid Al-Hamodi & Sameer D Salem & Sekaran Muniandy, 2015. "Serum Levels of Soluble CD26/Dipeptidyl Peptidase-IV in Type 2 Diabetes Mellitus and Its Association with Metabolic Syndrome and Therapy with Antidiabetic Agents in Malaysian Subjects," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-12, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:414:y:2001:i:6865:d:10.1038_414788a. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.