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Extending the lifespan of long-lived mice

Author

Listed:
  • Andrzej Bartke

    (School of Medicine, Southern Illinois University)

  • J. Chris Wright

    (School of Medicine, Southern Illinois University)

  • Julie A. Mattison

    (National Institute on Aging, NIH Animal Center)

  • Donald K. Ingram

    (National Institute on Aging, NIH Animal Center)

  • Richard A. Miller

    (University of Michigan)

  • George S. Roth

    (Gerontology Research Center)

Abstract

Ames dwarf mice are mutant mice that live about 50% longer than their normal siblings1,2,3 because they carry a 'longevity' gene, Prop1df, and in some phenotypic respects they resemble normal mice whose lifespan has been extended by restricted food intake2,4,5. Here we investigate whether these factors influence lifespan by similar or independent mechanisms, by deliberately reducing the number of calories consumed by Ames dwarf mice. We show that calorie restriction confers a further lifespan increase in the dwarfs, indicating that the two factors may act through different pathways.

Suggested Citation

  • Andrzej Bartke & J. Chris Wright & Julie A. Mattison & Donald K. Ingram & Richard A. Miller & George S. Roth, 2001. "Extending the lifespan of long-lived mice," Nature, Nature, vol. 414(6862), pages 412-412, November.
    • Handle: RePEc:nat:nature:v:414:y:2001:i:6862:d:10.1038_35106646
    DOI: 10.1038/35106646
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    Cited by:

    1. Colin Selman & Linda Partridge & Dominic J Withers, 2011. "Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1," PLOS ONE, Public Library of Science, vol. 6(1), pages 1-3, January.

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