Author
Listed:
- Michaël D. Katinka
(Genoscope, UMR CNRS 8030, CP 5706)
- Simone Duprat
(Genoscope, UMR CNRS 8030, CP 5706)
- Emmanuel Cornillot
(Parasitologie Moléculaire et Cellulaire, Laboratoire de Biologie des Protistes, UMR CNRS 6023, Université Blaise Pascal)
- Guy Méténier
(Parasitologie Moléculaire et Cellulaire, Laboratoire de Biologie des Protistes, UMR CNRS 6023, Université Blaise Pascal)
- Fabienne Thomarat
(Laboratoire de Biométrie et Biologie Evolutive, UMR CNRS 5558, Université Lyon I)
- Gérard Prensier
(Parasitologie Moléculaire et Cellulaire, Laboratoire de Biologie des Protistes, UMR CNRS 6023, Université Blaise Pascal)
- Valérie Barbe
(Genoscope, UMR CNRS 8030, CP 5706)
- Eric Peyretaillade
(Parasitologie Moléculaire et Cellulaire, Laboratoire de Biologie des Protistes, UMR CNRS 6023, Université Blaise Pascal)
- Philippe Brottier
(Genoscope, UMR CNRS 8030, CP 5706)
- Patrick Wincker
(Genoscope, UMR CNRS 8030, CP 5706)
- Frédéric Delbac
(Parasitologie Moléculaire et Cellulaire, Laboratoire de Biologie des Protistes, UMR CNRS 6023, Université Blaise Pascal)
- Hicham El Alaoui
(Parasitologie Moléculaire et Cellulaire, Laboratoire de Biologie des Protistes, UMR CNRS 6023, Université Blaise Pascal)
- Pierre Peyret
(Parasitologie Moléculaire et Cellulaire, Laboratoire de Biologie des Protistes, UMR CNRS 6023, Université Blaise Pascal)
- William Saurin
(Genoscope, UMR CNRS 8030, CP 5706)
- Manolo Gouy
(Laboratoire de Biométrie et Biologie Evolutive, UMR CNRS 5558, Université Lyon I)
- Jean Weissenbach
(Genoscope, UMR CNRS 8030, CP 5706)
- Christian P. Vivarès
(Parasitologie Moléculaire et Cellulaire, Laboratoire de Biologie des Protistes, UMR CNRS 6023, Université Blaise Pascal)
Abstract
Microsporidia are obligate intracellular parasites infesting many animal groups1. Lacking mitochondria and peroxysomes, these unicellular eukaryotes were first considered a deeply branching protist lineage2 that diverged before the endosymbiotic event that led to mitochondria. The discovery of a gene for a mitochondrial-type chaperone3,4,5 combined with molecular phylogenetic data6,7,8,9 later implied that microsporidia are atypical fungi that lost mitochondria during evolution. Here we report the DNA sequences of the 11 chromosomes of the ∼2.9-megabase (Mb) genome of Encephalitozoon cuniculi (1,997 potential protein-coding genes). Genome compaction is reflected by reduced intergenic spacers and by the shortness of most putative proteins relative to their eukaryote orthologues. The strong host dependence is illustrated by the lack of genes for some biosynthetic pathways and for the tricarboxylic acid cycle. Phylogenetic analysis lends substantial credit to the fungal affiliation of microsporidia. Because the E. cuniculi genome contains genes related to some mitochondrial functions (for example, Fe–S cluster assembly), we hypothesize that microsporidia have retained a mitochondrion-derived organelle.
Suggested Citation
Michaël D. Katinka & Simone Duprat & Emmanuel Cornillot & Guy Méténier & Fabienne Thomarat & Gérard Prensier & Valérie Barbe & Eric Peyretaillade & Philippe Brottier & Patrick Wincker & Frédéric Delba, 2001.
"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi,"
Nature, Nature, vol. 414(6862), pages 450-453, November.
Handle:
RePEc:nat:nature:v:414:y:2001:i:6862:d:10.1038_35106579
DOI: 10.1038/35106579
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Cited by:
- Pavel Dolezal & Michael J Dagley & Maya Kono & Peter Wolynec & Vladimir A Likić & Jung Hock Foo & Miroslava Sedinová & Jan Tachezy & Anna Bachmann & Iris Bruchhaus & Trevor Lithgow, 2010.
"The Essentials of Protein Import in the Degenerate Mitochondrion of Entamoeba histolytica,"
PLOS Pathogens, Public Library of Science, vol. 6(3), pages 1-13, March.
- Noelle V. Antao & Cherry Lam & Ari Davydov & Margot Riggi & Joseph Sall & Christopher Petzold & Feng-Xia Liang & Janet H. Iwasa & Damian C. Ekiert & Gira Bhabha, 2023.
"3D reconstructions of parasite development and the intracellular niche of the microsporidian pathogen Encephalitozoon intestinalis,"
Nature Communications, Nature, vol. 14(1), pages 1-16, December.
- Nathan Jespersen & Kai Ehrenbolger & Rahel R. Winiger & Dennis Svedberg & Charles R. Vossbrinck & Jonas Barandun, 2022.
"Structure of the reduced microsporidian proteasome bound by PI31-like peptides in dormant spores,"
Nature Communications, Nature, vol. 13(1), pages 1-14, December.
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