IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v414y2001i6860d10.1038_n35101999.html
   My bibliography  Save this article

Identification of the cellular receptor for anthrax toxin

Author

Listed:
  • Kenneth A. Bradley

    (McArdle Laboratory for Cancer Research, University of Wisconsin—Madison
    Biological and Biomedical Sciences Graduate Program)

  • Jeremy Mogridge

    (Harvard Medical School
    University of Toronto)

  • Michael Mourez

    (Harvard Medical School)

  • R. John Collier

    (Harvard Medical School)

  • John A. T. Young

    (McArdle Laboratory for Cancer Research, University of Wisconsin—Madison)

Abstract

The tripartite toxin secreted by Bacillus anthracis, the causative agent of anthrax, helps the bacterium evade the immune system and can kill the host during a systemic infection. Two components of the toxin enzymatically modify substrates within the cytosol of mammalian cells: oedema factor (OF) is an adenylate cyclase that impairs host defences through a variety of mechanisms including inhibiting phagocytosis1,2; lethal factor (LF) is a zinc-dependent protease that cleaves mitogen-activated protein kinase kinase and causes lysis of macrophages3,4,5. Protective antigen (PA), the third component, binds to a cellular receptor and mediates delivery of the enzymatic components to the cytosol. Here we describe the cloning of the human PA receptor using a genetic complementation approach. The receptor, termed ATR (anthrax toxin receptor), is a type I membrane protein with an extracellular von Willebrand factor A domain that binds directly to PA. In addition, a soluble version of this domain can protect cells from the action of the toxin.

Suggested Citation

  • Kenneth A. Bradley & Jeremy Mogridge & Michael Mourez & R. John Collier & John A. T. Young, 2001. "Identification of the cellular receptor for anthrax toxin," Nature, Nature, vol. 414(6860), pages 225-229, November.
    • Handle: RePEc:nat:nature:v:414:y:2001:i:6860:d:10.1038_n35101999
    DOI: 10.1038/n35101999
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/n35101999
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/n35101999?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kuo-Sheng Hsu & James M. Dunleavey & Christopher Szot & Liping Yang & Mary Beth Hilton & Karen Morris & Steven Seaman & Yang Feng & Emily M. Lutz & Robert Koogle & Francesco Tomassoni-Ardori & Saurabh, 2022. "Cancer cell survival depends on collagen uptake into tumor-associated stroma," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:414:y:2001:i:6860:d:10.1038_n35101999. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.