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Partial leptin deficiency and human adiposity

Author

Listed:
  • I. Sadaf Farooqi

    (Addenbrooke's Hospital)

  • Julia M. Keogh

    (Addenbrooke's Hospital)

  • Sri Kamath

    (City Hospital)

  • Sarah Jones

    (MRC Human Nutrition Research)

  • William T. Gibson

    (Alberta Children's Hospital)

  • Rebecca Trussell

    (Alberta Children's Hospital)

  • Susan A. Jebb

    (MRC Human Nutrition Research)

  • Gregory Y. H. Lip

    (City Hospital)

  • Stephen O'Rahilly

    (Addenbrooke's Hospital)

Abstract

The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice1 and humans2,3 without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically partially deficient in leptin, and show that differences in circulating leptin levels within the range found in normal human populations can directly influence the laying down of fat tissue (adiposity).

Suggested Citation

  • I. Sadaf Farooqi & Julia M. Keogh & Sri Kamath & Sarah Jones & William T. Gibson & Rebecca Trussell & Susan A. Jebb & Gregory Y. H. Lip & Stephen O'Rahilly, 2001. "Partial leptin deficiency and human adiposity," Nature, Nature, vol. 414(6859), pages 34-35, November.
    • Handle: RePEc:nat:nature:v:414:y:2001:i:6859:d:10.1038_35102112
    DOI: 10.1038/35102112
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