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Auxin transport inhibitors block PIN1 cycling and vesicle trafficking

Author

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  • Niko Geldner

    (Zentrum für Molekularbiologie der Pflanzen, Universität Tübingen)

  • Jiří Friml

    (Max-Delbrück-Laboratorium in der Max-Planck-Gesellschaft
    Faculty of Science, Masaryk University
    Universität Tübingen)

  • York-Dieter Stierhof

    (Zentrum für Molekularbiologie der Pflanzen, Universität Tübingen)

  • Gerd Jürgens

    (Zentrum für Molekularbiologie der Pflanzen, Universität Tübingen)

  • Klaus Palme

    (Max-Delbrück-Laboratorium in der Max-Planck-Gesellschaft)

Abstract

Polar transport of the phytohormone auxin mediates various processes in plant growth and development, such as apical dominance, tropisms, vascular patterning and axis formation1,2. This view is based largely on the effects of polar auxin transport inhibitors. These compounds disrupt auxin efflux from the cell but their mode of action is unknown3. It is thought that polar auxin flux is caused by the asymmetric distribution of efflux carriers acting at the plasma membrane4. The polar localization of efflux carrier candidate PIN1 supports this model4. Here we show that the seemingly static localization of PIN1 results from rapid actin-dependent cycling between the plasma membrane and endosomal compartments. Auxin transport inhibitors block PIN1 cycling and inhibit trafficking of membrane proteins that are unrelated to auxin transport. Our data suggest that PIN1 cycling is of central importance for auxin transport and that auxin transport inhibitors affect efflux by generally interfering with membrane-trafficking processes. In support of our conclusion, the vesicle-trafficking inhibitor brefeldin A mimics physiological effects of auxin transport inhibitors.

Suggested Citation

  • Niko Geldner & Jiří Friml & York-Dieter Stierhof & Gerd Jürgens & Klaus Palme, 2001. "Auxin transport inhibitors block PIN1 cycling and vesicle trafficking," Nature, Nature, vol. 413(6854), pages 425-428, September.
    • Handle: RePEc:nat:nature:v:413:y:2001:i:6854:d:10.1038_35096571
    DOI: 10.1038/35096571
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    Cited by:

    1. Sivamathini Rajappa & Pannaga Krishnamurthy & Hua Huang & Dejie Yu & Jiří Friml & Jian Xu & Prakash P. Kumar, 2024. "The translocation of a chloride channel from the Golgi to the plasma membrane helps plants adapt to salt stress," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Jing Zhang & Ewa Mazur & Jozef Balla & Michelle Gallei & Petr Kalousek & Zuzana Medveďová & Yang Li & Yaping Wang & Tomáš Prát & Mina Vasileva & Vilém Reinöhl & Stanislav Procházka & Rostislav Halouzk, 2020. "Strigolactones inhibit auxin feedback on PIN-dependent auxin transport canalization," Nature Communications, Nature, vol. 11(1), pages 1-10, December.

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