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Intercellular movement of the putative transcription factor SHR in root patterning

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  • Keiji Nakajima

    (New York University
    Nara Institute of Science and Technology)

  • Giovanni Sena

    (New York University)

  • Tal Nawy

    (New York University)

  • Philip N. Benfey

    (New York University)

Abstract

Positional information is pivotal for establishing developmental patterning in plants1,2,3, but little is known about the underlying signalling mechanisms. The Arabidopsis root radial pattern is generated through stereotyped division of initial cells and the subsequent acquisition of cell fate4. short-root (shr) mutants do not undergo the longitudinal cell division of the cortex/endodermis initial daughter cell, resulting in a single cell layer with only cortex attributes5,6. Thus, SHR is necessary for both cell division and endodermis specification5,6. SHR messenger RNA is found exclusively in the stele cells internal to the endodermis and cortex, indicating that it has a non-cell-autonomous mode of action6. Here we show that the SHR protein, a putative transcription factor, moves from the stele to a single layer of adjacent cells, where it enters the nucleus. Ectopic expression of SHR driven by the promoter of the downstream gene SCARECROW (SCR) results in autocatalytic reinforcement of SHR signalling, producing altered cell fates and multiplication of cell layers. These results support a model in which SHR protein acts both as a signal from the stele and as an activator of endodermal cell fate and SCR-mediated cell division.

Suggested Citation

  • Keiji Nakajima & Giovanni Sena & Tal Nawy & Philip N. Benfey, 2001. "Intercellular movement of the putative transcription factor SHR in root patterning," Nature, Nature, vol. 413(6853), pages 307-311, September.
    • Handle: RePEc:nat:nature:v:413:y:2001:i:6853:d:10.1038_35095061
    DOI: 10.1038/35095061
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    Cited by:

    1. Hinako Tamotsu & Koji Koizumi & Alejandro Villar Briones & Reina Komiya, 2023. "Spatial distribution of three ARGONAUTEs regulates the anther phasiRNA pathway," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Rodolfo A. Maniero & Cristiana Picco & Anja Hartmann & Felipe Engelberger & Antonella Gradogna & Joachim Scholz-Starke & Michael Melzer & Georg Künze & Armando Carpaneto & Nicolaus Wirén & Ricardo F. , 2024. "Ferric reduction by a CYBDOM protein counteracts increased iron availability in root meristems induced by phosphorus deficiency," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Mitchell P Levesque & Teva Vernoux & Wolfgang Busch & Hongchang Cui & Jean Y Wang & Ikram Blilou & Hala Hassan & Keiji Nakajima & Noritaka Matsumoto & Jan U Lohmann & Ben Scheres & Philip N Benfey, 2006. "Whole-Genome Analysis of the SHORT-ROOT Developmental Pathway in Arabidopsis," PLOS Biology, Public Library of Science, vol. 4(5), pages 1-1, May.

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