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A new receptor for β-glucans

Author

Listed:
  • Gordon D. Brown

    (Sir William Dunn School of Pathology, University of Oxford)

  • Siamon Gordon

    (Sir William Dunn School of Pathology, University of Oxford)

Abstract

The carbohydrate polymers known as β-1,3-d-glucans exert potent effects on the immune system — stimulating antitumour and antimicrobial activity, for example — by binding to receptors on macrophages and other white blood cells and activating them. Although β-glucans are known to bind to receptors, such as complement receptor 3 (ref. 1), there is evidence that another β-glucan receptor is present on macrophages. Here we identify this unknown receptor as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of β-glucans.

Suggested Citation

  • Gordon D. Brown & Siamon Gordon, 2001. "A new receptor for β-glucans," Nature, Nature, vol. 413(6851), pages 36-37, September.
    • Handle: RePEc:nat:nature:v:413:y:2001:i:6851:d:10.1038_35092620
    DOI: 10.1038/35092620
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    Cited by:

    1. Stacy K. Thomas & Max M. Wattenberg & Shaanti Choi-Bose & Mark Uhlik & Ben Harrison & Heather Coho & Christopher R. Cassella & Meredith L. Stone & Dhruv Patel & Kelly Markowitz & Devora Delman & Micha, 2023. "Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Han Gao & Sen Li & Zhengyi Lan & Da Pan & Gonna Somu Naidu & Dan Peer & Chenyi Ye & Hangrong Chen & Ming Ma & Zehua Liu & Hélder A. Santos, 2024. "Comparative optimization of polysaccharide-based nanoformulations for cardiac RNAi therapy," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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